中脑导水管周围灰质内β-内啡肽对催产素增强电针镇痛的影响  

EFFECT OF β-ENDORPHIN ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY OXYTOCIN IN PERIAQUEDUCTAI GRAY OF RATS

作　　者：刘文彦[1] 闫瑞臻[1] 王曙光[1] 张艳霞[1] 冀强[1] 

机构地区：[1]济宁医学院生理学教研室

出　　处：《济宁医学院学报》2002年第4期4-6,共3页Journal of Jining Medical University

基　　金：山东省自然科学基金资助课题 (No Q98C0 112 4)

摘　　要：目的　探讨中脑导水管周围灰质 (PAG)内催产素 (OT)与内源性 β -内啡肽在电针镇痛中的相互关系。方法　以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛反应的指标 ,观察向PAG内注入OT和抗 β -内啡肽血清 ,对大鼠电针镇痛效应的影响。 结果　PAG内注入抗 β -内啡肽血清后 ,能明显降低电针镇痛的效应 ;但预先注入抗 β -内啡肽血清 ,并不能阻断OT增强电针镇痛的作用。 结论　PAG内OT在电针镇痛中的作用不依赖于PAG内的内源性 βObjective To study the effect of oxytocin(O T) on electroacupuncture analgesia in periaqueductal gray(PAG) and its relation to endogenous β-endorphin.Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold. Results OT administration induced a enhancement of electroacupu ncture analgesia.Furthermore,pre-injection of AEPS in PAG not could weaken ana lgesia effect of OT.Conclusion These data suggest the enhancement of electroacupunc ture analgesia by OT is not dependent upon the β-endorphin in PAG.

关 键 词：中脑 导水管周围灰质 Β-内啡肽 催产素 电针镇痛 

分 类 号：R246.2[医药卫生—针灸推拿学]