双(4,5-二氮杂芴酮)缩对,对'-二氨基二苯甲烷桥联的二(邻菲咯啉合铜(Ⅱ))的合成及其与DNA作用的光谱研究  

Synthesis and Spectroscopic DNA Binding Studies of 1,1′-Bis(nitrilomethylidyne-4,5-diazafluoren)-4,4′-(μ-methylene)bisphenyl Bridged Bis(1,10-phenanthrolinocopper(Ⅱ)) Complex

作　　者：钟文添[1] 吴建中[1] 

机构地区：[1]华南师范大学化学系，广州 510631

出　　处：《无机化学学报》2003年第2期196-200,共5页Chinese Journal of Inorganic Chemistry

基　　金：广东省自然科学基金资助项目(No.984193)

摘　　要：A new bimetallic Cu?complex, [(phen)Cu(μ bdmp)Cu(phen)](ClO4)4·2H2O, where phen and bdmp denote 1,10 phenanthroline and 1,1′ bis(nitrilomethylidyne 4,5 diazafluoren) 4,4′ (μ methylene)bisphenyl respectively was synthesized and its DNA binding behavior was studied by photophysical methods. It has been found that calf thymus DNA could result in significant decrease both in electronic absorption and fluorescent emission of the complex. The fluorescence quenching by ferrocyanide could be reduced to some extent for the complexin presence of DNA. These facts suggest that this dicopper?complex binds to double helix DNA by partial intercalation.A new bimetallic Cu?complex, [(phen)Cu(μ bdmp)Cu(phen)](ClO4)4·2H2O, where phen and bdmp denote 1,10 phenanthroline and 1,1′ bis(nitrilomethylidyne 4,5 diazafluoren) 4,4′ (μ methylene)bisphenyl respectively was synthesized and its DNA binding behavior was studied by photophysical methods. It has been found that calf thymus DNA could result in significant decrease both in electronic absorption and fluorescent emission of the complex. The fluorescence quenching by ferrocyanide could be reduced to some extent for the complexin presence of DNA. These facts suggest that this dicopper?complex binds to double helix DNA by partial intercalation.

关 键 词：合成 DNA 光谱 Cu(Ⅱ) 双核配合物 邻菲咯啉 小牛胸腺DNA 铜 相互作用 双-(4 5-二氮杂芴酮)缩对 对′-二氨基二苯甲烷 

分 类 号：Q523[生物学—生物化学]