选择性一氧化氮合成酶抑制剂1400W对创伤后脑组织保护作用的研究  

Neuroprotection of 1400W, a Selective Inhibitor of Inducible Nitric Oxide Synthetase in Rat after Traumatic Brain Injury

作　　者：张世明[1] 蒋小齐[2] 邵竹平[2] 杨天明[3] 

机构地区：[1]苏州大学附属第一医院神经外科,苏州215006 [2]南京江北人民医院,南京210000 [3]东南大学医学院附属医院神经外科,南京210009

出　　处：《苏州大学学报（医学版）》2002年第6期650-652,655,共4页Suzhou University Journal of Medical Science

基　　金：国家教委留学回国人员科研启动基金资助 (教外司留 [1997] 832号 )

摘　　要：目的　探讨选择性一氧化氮合成酶抑制剂 140 0W对外伤性脑组织的保护作用。方法　建立大鼠自由落体脑外伤模型 ,测定脑外伤后生理盐水组和治疗组不同时期脑组织NO含量 ,同时观察脑组织病理及超微结构的改变 ,将两组结果进行比较。结果　 140 0W能明显降低NO的含量 ,改善脑外伤后脑组织的病理变化和超微结构改变。结论　 140Objective To investigate the protective effect of N-[3-(aminomethyl)benzyl] acetamidine (1400W), a selective inhibitor of inducible calcium-independent nitric oxide synthetase (iNOS), to the traumatic brain tissue.Methods The brain injury model of the rat was developed by dropping weight. The concentrations of NO in traumatic rat brain tissue at different time were determined in the treated group and the control group, while the histopathology and ultrastructure changes were observed. The experimental results were compared in the two groups. Results NO content decreased significantly.Histopathological tissue and ultrastructure improved significantly by 1400W in treated group.Conclusion 1400W has obvious protective effect on the post-traumatic brain tissue.

关 键 词：脑损伤 1400W 一氧化氮合成酶 一氧化氮 

分 类 号：R651.15[医药卫生—外科学]