HBsAg阳性肝病患者检测AFP的临床意义及其相关分析  

Clinical Observation and Relevant Analysis of Detectingα-Fetoprotein of Patients with Hepatic Disease

作　　者：俞伟[1] 阎记灵 

机构地区：[1]长治医学院附属和平医院中医科,046000 [2]长治市卫校

出　　处：《长治医学院学报》2002年第3期178-180,共3页Journal of Changzhi Medical College

摘　　要：应用火箭电泳法检测 2 2 7例HBsAg阳性肝病患者的血清甲胎球蛋白 (AFP)水平 ,并与血清谷丙酸转氨酶 (ALT) ,天门冬氨酸转移酶 (AST)和碱性磷酸酶 (ALP)进行对比分析。结果表明 ,AFP异常率 ,慢性肝炎 (慢迁肝 ) <急性肝炎 <慢性活动性肝炎 (慢活肝 ) <肝硬化 <重症肝炎 <原发性肝癌 ,AFP异常值 ;慢迁肝 <急性肝炎 <重症肝炎 <慢活肝 <肝硬化 <原发性肝癌 ,原发性肝癌AFP升高多>40 0 μg/μL ,其AST多异常且增高比ALT明显 ,慢活肝肝硬化AFP增高在 1 5 0 μg/μL～ 30 0 μg/μL ,ALT、AST异常较原发性肝癌明显 ;ALP增高在原发性肝癌为 71 % ,且幅度较大 ,其余呈不同程度、不同比例增高 ,慢迁肝则均正常。提示原发性肝癌与AFP升高幅度呈正相关 ,急性肝炎和重症肝炎AFP为一过性升高 。Serumα- fetoprotein (AFP) of 227 HBsAg(+) patients with hepatic disease were detected by rocket electrophoresis and contrasted with alaning transamiase (ALT),aspartic acid transamiase (AST)and alkalium phosphatase(ALP) at same time.The results were as follows:① abnormal rate of AFP :chronic persisting hepatitis (CPH)<acute hepatitis(AH)<chronic active hepatitis(CAH) <cirrhosis<severe hepatitis(SH)<primary hepatic carcinoma(PHC);(②the average value of AFP:CPH<AH<SH<CAH<cirrhosis<PHC;③AFP of the patients with PHC was obvious high and more than 400μg/L, AST of most patient with PHC was abnormal and markedly increased than ALT;④the rising range of AFP in patient with CAH, cirrhosis was 150-300μg/L,and ALT,AST were obvious higher than those of the PHC;⑤ALP of the patient with PHC was markedly rising(71%),ALT and AST were slightly rising in different degree,but all indexes of patients with CPH were normal.The results manifested that the rising range of AFP and severe condition of PHC were positive correlation,AFP of patients with AH and SH was transient rising. The patients with CAH and cirrosis were high risk group of PHC

关 键 词：肝功能试验 慢性肝病 诊断学 甲胎蛋白 AFP HBsAg阳性肝病 

分 类 号：R512.6[医药卫生—内科学]