云芝多糖对应激大鼠学习记忆障碍的影响  

INFLUENCE OF CORIOLUS VERSICOLAR POLYSACCHARIDE ON RAT'S LEARNING AND MEMORY DISTURBANCE CAUSED BY STRESS

作　　者：胡旺平[1] 李雪梅[1] 李立中[1] 化长林[1] 

机构地区：[1]咸宁医学院生理学教研室,咸宁437100

出　　处：《中国中医药科技》2003年第1期32-33,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的 :观察云芝多糖对应激引起大鼠学习记忆损害的影响。方法 :通过Morris水迷宫实验观察空间学习能力和空间记忆能力 ,并检测大鼠海马内SOD活性和MDA含量。结果 :云芝多糖可明显缩短大鼠Morris水迷宫平均训练潜伏期 ,大鼠在 4个象限中停留时间百分比以原放置平台象限为长 ,可明显提高大鼠海马SOD活性 ,降低MDA含量。结论Objective:To discover the influence of Coriolus Versicolar polysaccharide on rat's learning and memory damages caused by stress.Method:Observing the spatial memory by Morris' Water labyrinth experiment and determining SOD activity and MDA content in rat's hippocampal tissue.Results: Coriolus Versicolar polysaccharide could obviously shorten training latent period of rat in Morris'water labyrinth,the stay time of rat on platform was longer than that in other quadrants.it could significantly increase the SOD activity and decrease the content of MDA.Conclusion: Coriolus Versicolar polysaccharide could significantly improve the learning and momery disturbance of rat caused by stress.

关 键 词：应激 云芝多糖 药理学 学习 记忆 动物实验 

分 类 号：R285.5[医药卫生—中药学] R277.7[医药卫生—中医学]