去氢骆驼蓬碱明胶微球药物含量及热解稳定性研究  

Study on the Content of Hydrochloric Harmine and Heat Stability of Harmine Gelatin Microspheres

作　　者：翁幼武[1] 李岩[1] 孙殿甲[1] 

机构地区：[1]新疆医科大学药学院,乌鲁木齐市830054

出　　处：《中国药房》2003年第1期15-17,共3页China Pharmacy

基　　金：新疆维吾尔自治区科委基金资助项目 (2000-K01-05-02-03)

摘　　要：目的 :考察去氢骆驼蓬碱明胶微球 (HM -GMS)中盐酸去氢骆驼蓬碱 (HM )含量测定方法及微球热解稳定性。方法 :用紫外分光光度 (UV)法和反相高效液相色谱 (RP -HPLC)法比较HM -GMS中表面药物及总药物量 ;用差示热分析比较原料、空白微球及HM -GMS的DTA曲线 ,计算热解活化能、频率因子。结果 :UV法和HPLC法测得表面药物量差异无显著性 (P>0 05) ,总药物量差异有显著性 (P<0 05) ,其中RP -HPLC法测得结果较小 ;热解活化能为93 37kJ/mol,频率因子为2 304×1013/min。结论 :UV法简便、快捷 ,RP -HPLC法更精确 ;HM -GMS热稳定性较好。OBJECTIVE:To establish a method for detecting the hydrochloric harmine(HM) content and evaluate the heat stability of harmine gelatin microspheres.METHODS:Using UV and RP-HPLC methods to detect the surface and total HM content of microspheres;Using pyrolytic activation energy and frequency factor to test heat stability.RESULTS:Between UV and RP-HPLC test,there was no statistical difference(P>0.05) in surface HM;however,the total content obtained from RP-HPLC was smaller.The pyrolytic activation energy was 93.37kJ/mol,frequency factor was 2.304×1013/min.CONCLUS_ION:UV-spectrophotometry is more simple and RP-HPLC is more precise in detection.HM-GMS is considerably heat-stable.

关 键 词：热解稳定性 去氢骆驼蓬碱盐酸盐 微球 含量测定 差示热分析 

分 类 号：R927.11[医药卫生—药学] R927.2