口服国产尼莫地平胶囊在健康人体的药代动力学研究  

Pharmacokinetics of Domestic Nimodipin Capsule in Healthy Volunteers

作　　者：李祖惠[1] 何海霞[2] 韩敏[1] 周远大[2] 

机构地区：[1]重庆医科大学第一附属医院药剂科,重庆市400016 [2]重庆医科大学第一附属医院临床药理研究室,重庆市400016

出　　处：《中国药房》2003年第1期31-32,共2页China Pharmacy

摘　　要：目的 :探讨国产尼莫地平胶囊在健康人体的药代动力学。方法 :用高效液相色谱法测定12名男性健康志愿者口服尼莫地平胶囊后的血药浓度 ;用3p97软件计算有关药代动力学参数。结果 :该制剂的T1/2β(h)、Tmax、Cmax、AUC0～6 分别为 (2 53±1 18)h、(0 42±0 14)h、(75 41±27 65)ng/ml、(155 85±49 54)ng/(h·ml) ,药 -时曲线符合二室开放模型。结论 :该制剂在体内滞留时间短 ,于0 4h左右达血药浓度峰值 ,其测定数据可为临床用药提供参考。OBJECTIVE:To study the pharmacokinetics of domestic nimodipin capsule in 12 healthy volunteers.METHO_DS:An oral dose of 60mg nimodipin capsule was given to healthy volunteers,and plasma concentrations of nimodipin were determined by HPLC.The data were fitted by 3p97 program.RESULTS:The results showed that the plasma concentration-time curves profile conformed to a two compartment open model.The T1/2β,Tmax,Cmax,AUC(0～6) of this product was(2.53±1.18)h,(0.42±0.14)h,(75.41±27.65)ng/ml and (155.85±49.54)ng/(h·ml),respectively.CONCLUSION:Retention time of this preparation in healthy volunteers is short with Tmax of about 0.4h,which provides useful information for clinical practice.

关 键 词：口服 胶囊 尼莫地平 药代动力学 高效液相色谱法 NMD 血药浓度 

分 类 号：R969.1[医药卫生—药理学] R972.4[医药卫生—药学]