炙甘草汤有效成分及其配伍对缺血再灌离体大鼠心脏触发活动及心肌损伤的影响  

Effect of Active Components of Zhi Ga ncao Decoction and Their Combinatio n on Triggered Activity and Myocar-dial Damage in Isolated Ischemia -reperfusion Rat Heart

作　　者：李兴高[1] 陈奇[1] 黄梦雨[2] 毕明[1] 陈兰英[1] 

机构地区：[1]江西中医学院药学系,南昌330006 [2]香港理工大学现代中药研究所,广东深圳518057

出　　处：《中药新药与临床药理》2003年第1期6-9,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金课题(编号39860084)。

摘　　要：目的观察炙甘草汤有效成分,包括甘草酸单铵盐、人参总皂苷、麦冬总皂苷及其配伍对缺血再灌诱发的离体大鼠心脏触发活动的影响。方法采用Langendroff非循环式离体心脏灌流,单相动作电位记录法。结果与结论炙甘草汤总提物、单个有效成分及其配伍能明显降低缺血再灌诱发的离体大鼠心脏触发活动发生率,能明显抑制再灌性心律失常的出现,对缺血再灌性心肌损伤有显著保护作用,且有效成分配伍的效应与剂量呈一定的正相关性。Objective To observe the effect of active components(glycyrrhizic acid monoaminate,total ginsenoside and to-tal ophiopogonoside)of Zhi Gancao Decoction(ZGD)and their combination on the triggered activity and myocardial dam-age in the isolated ischemia -reperfusion rat heart.Methods Isolated rat heart was treated with L angendroff perfusion and monophase action potential technology was applied.Results &Conclusion Total extract of ZGD,single active c omponents and their combination can markedly l ower the incidence of cardiac triggered activity,prevent the myocardiu m from injury and decrease the incidence of arrhythmia induced by ischemia -reperfusion in rats and the effects of their com bination are positively related to the doses.

关 键 词：炙甘草汤 药理学 心脏 药物作用 中药 病理生理学 心肌再灌注损伤 

分 类 号：R285.5[医药卫生—中药学]