痛风冲剂抗痛风作用的实验研究  

Experimental Study of Gout Granule f or Gout

作　　者：宁炼[1] 金若敏[1] 吴耀平[1] 张海贵[1] 祁海宏[1] 张明[2] 李斌[2] 

机构地区：[1]上海中医药大学,上海200032 [2]岳阳中西医结合医院,上海200437

出　　处：《中药新药与临床药理》2003年第1期28-30,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的通过对痛风冲剂抗痛风与抗炎的作用研究,探讨该药的药效学作用,为临床应用提供依据。方法运用尿酸钠致大鼠踝关节肿胀法、次黄嘌呤致小鼠高尿酸血症法观察其抗痛风作用;二甲苯致小鼠耳廓肿胀法、角叉菜胶致大鼠足跖肿胀法和羧甲基纤维素囊袋法观察其抗炎作用。结果痛风冲剂有明显的降低高尿酸血症小鼠血尿酸水平和抗炎作用,并具有增加高尿酸血症小鼠尿尿酸排出的趋势。结论痛风冲剂具有抗痛风急性发作的作用。Objective To investigate the effect of Gout Gra nule(GG)for gout.Methods Gout -relieving effect of GG was observed in rats with adjuvant arthritis induced by sodium urate and i n mice with hyperuricemia induced by hypoxan-thine.Anti -inflammation of GG was i nvestigated in mice with xylene -ind uced auricular swelling and in rats with edema of hind paw induced by injection of carrageenin.WBC migratory response c aused by carboxymethylcellulose(CMC)in mice was also observed.Results GG could reduce the blood level of uric acid and inhibit acute inflammatio n in model ani-mals and also tended to promote the elimination of uric acid.Conclusion GG had a remarkable effect on the acut e attack of gout.

关 键 词：痛风冲剂 药理学 痛风 中药疗法 疾病模型 

分 类 号：R285.5[医药卫生—中药学]