穿心莲内酯、脱水穿心莲内酯和穿心莲SFE-CO_2萃取物的热降解动力学  

Heat -Degradation Kinetic Study of Andrographolide,Dehydroandrograp holide and SFE -CO_2 Extract from Herba Andrographitis

作　　者：黄晓丹[1] 苏子仁[1] 赖小平[1] 林树海[1] 劳洁[1] 董晓兵[1] 颜玉贞 

机构地区：[1]广州中医药大学新药中心,广州510405 [2]广州市药品检定所,广州510160

出　　处：《中药新药与临床药理》2003年第1期53-56,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的了解穿心莲内酯、脱水穿心莲内酯在不同状态下的热降解动力学。方法采用HPLC法测定穿心莲内酯、脱水穿心莲内酯及穿心莲SFE-CO2萃取物,在不同温度、不同时点的浓度,并按一级动力学方程和Arrhenius公式进行数据处理,求算有效期。结果在室温25℃条件下,纯品穿心莲内酯有效期为2373d,脱水穿心莲内酯为657516d,穿心莲SFE-CO2萃取物穿心内酯为101d,穿心莲总内酯为122d。结论穿心莲内酯、脱水穿心莲内酯在纯品状态下稳定性高于穿心莲SFE-CO2萃取物,穿心莲内酯稳定性低于脱水穿心莲内酯。Objective To investigate the heat -degradatio n kinetics of andrographolide and dehydroandrographolide under different conditions.Methods HPLC was adopted to detect concentra tion of andrographolide,dehydroan drographolide and SFE -CO 2 extract from Herba Andrographitis a t different temperature and in vario us times.Then the data was managed with first grade dynamic equation an d Arrhenius formula to obtain their e xpiry period(EP).Results At room temperature of 25℃,EP of andrographolide and deh yandrographolide in pure condition last 2373days and 657516days respectively,and that of andrographolide and tota l lactone in SFE -CO 2 extract condition last 101days and 122days respectively.Conclusion EP of andrographolide and dehydroan drographolide are much longer in pur e condition than that in SFE -CO 2 extract condition and EP of androgra pholide is much shorter than that of dehyandrographolide.

关 键 词：穿心莲内酯 药物稳定性 热重法 高压液相色谱法 热降解动力学 

分 类 号：R284.1[医药卫生—中药学]