米非司酮加倍给药用于终止早孕的临床效果观察  

The Clinical Observation of Double Dose of Mifepristone and Misoprostal in Termination of Early Pregnancy.

作　　者：王玮[1] 刘晓瑗[1] 李玲[1] 陈希珍[1] 金毓翠[1] 

机构地区：[1]上海第二医科大学瑞金医院,200025

出　　处：《中国计划生育学杂志》2003年第1期39-41,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨米非司酮配伍米索前列醇终止早孕最佳剂量方案。方法:将600例早孕,且孕囊平均直径≤25mm,要求药物终止妊娠的妇女,随机分为对照组和观察组各300例。对照组第1、2天上午服米非司酮50mg,12h后服25mg,总剂量150mg,第3天晨服米索前列醇600μg,4h后服400μg,总量1000μg。观察组米非司酮首次剂量50mg,继后每12h服25mg(共6天),总剂量300mg,第3天晨服米索前列醇600μg,第4～6天晨各服200μg,总量1200μg。结果:完全流产率对照组94.3％,观察组92.5％(P>0.05)。出血时间对照组13.6±6.84天,观察组13.3±7.08天(P>0.05)。孕囊排出时间、转经间隔时间和经期均相似。结论:米非司酮配伍米索前列醇加倍给药不能改善药物流产结局。Objective:To investigate the optimal does of mifepristone and misoprostal in termination of early pregnancy. Methods;The randomized comparative study consisted of 600 pregnant women whose average diameter of gestational sac <25 mm. They were randomly divided into 2 groups,300 cases in each group. The women in control group took mifepristone 50mg in the morning and 25mg in the evening in dl ~ 2 (total a-mount was 150mg) , then took misoprostal 600u,g in the morning and 400ug 4 hours later on d3 (total amount was 1mg). The women in study group took mifepristone 50mg first and then 25mg every 12 hours in 6 days (total amount was 300mg) ,then took misoprostal 600ug in the morning on d3 and 200ug/d on d4 ~6(total amount was 1. 2mg). Result; The complete abortion rate was 94. 3% in control group and 92. 5% in study group(P>0. 05). The bleeding duration was 13.6±6.84 and 13.3±7. 08 days (P > 0. 05). The expulse time of gestational sac and the recovery of menstruation were similar. Conclusion; Double dose of mifepristone and misoprostal can not improve the results of medicinal abortion.

关 键 词：米非司酮 终止早孕 临床 效果观察 终止妊娠 剂量 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]