次声对大鼠肾脏单胺氧化酶、GSH-Px、SOD活性和MDA含量的影响  

Effects of infrasound on monoamine oxidase, GSH-Px, SOD and lipid perox idation in rat kidneys

作　　者：陈耀明[1] 叶琳[1] 高双斌[1] 龚书明[1] 陈景元[1] 骆文静[1] 刘秀红[1] 杨瑞华[1] 

机构地区：[1]第四军医大学预防医学系劳动与环境卫生学教研室,陕西西安710033

出　　处：《第四军医大学学报》2003年第2期113-115,共3页Journal of the Fourth Military Medical University

基　　金：全军重点课题之分题 (96Z0 4 2 )

摘　　要：AIM: To investigate the changes of monoami ne oxidase (MAO), glutathione peroxidase(GSH-Px), superoxide dismutase (SOD ), and malondialdehyde (MDA) in the kidneys of rats exposed to 8 Hz, 130 dB i nfrasound at different times, and to explore the mechanism of kidney injury caus ed by infrasound. METHODS : Thirty-five male SD rats were random ly divided into five groups. Group 1 served as control group, and group 2 to gro up 5 were exposed 2 hours per day to 8 Hz 130 dB infrasound for 1 wk, 2 wk, 3 wk and 4 wk, respectively. RESULTS: MAO activities in all the inf rasound exposed groups increased [(97±28～108±8) nkat·g -1 ], but they s howed no significant difference (P>0 05). GSH-Px activ ities in 4 wk group increased significantly [(181±34～228±24) nkat·g -1 ,[WTBX] P<0 05]. SOD activities remained unchanged followin g exposure to infrasound (. SOD activities remained unchanged followin g exposure to infrasound (P>0 05). MDA concentration i n the 1 wk and 2 wk groups increased significantly[(1 93±0 49～2 55±0 51) μmol·g -1 ,[WTBX]P<0 05], , and it returned to the cont rol level in the 3 wk and 4 wk(1 93±0 49～1 87±0 26)μmol· g -1 . CONCLUSION: The results suggest that the lipid peroxidati on in the kidneys of infrasound exposed rats can be increased and infrasound may play an important role in kidney injury.AIM: To investigate the changes of monoami ne oxidase (MAO), glutathione peroxidase(GSH-Px), superoxide dismutase (SOD ), and malondialdehyde (MDA) in the kidneys of rats exposed to 8 Hz, 130 dB i nfrasound at different times, and to explore the mechanism of kidney injury caus ed by infrasound. METHODS : Thirty-five male SD rats were random ly divided into five groups. Group 1 served as control group, and group 2 to gro up 5 were exposed 2 hours per day to 8 Hz 130 dB infrasound for 1 wk, 2 wk, 3 wk and 4 wk, respectively. RESULTS: MAO activities in all the inf rasound exposed groups increased [(97±28～108±8) nkat·g -1 ], but they s howed no significant difference (P>0 05). GSH-Px activ ities in 4 wk group increased significantly [(181±34～228±24) nkat·g -1 ,[WTBX] P<0 05]. SOD activities remained unchanged followin g exposure to infrasound (. SOD activities remained unchanged followin g exposure to infrasound (P>0 05). MDA concentration i n the 1 wk and 2 wk groups increased significantly[(1 93±0 49～2 55±0 51) μmol·g -1 ,[WTBX]P<0 05], , and it returned to the cont rol level in the 3 wk and 4 wk(1 93±0 49～1 87±0 26)μmol· g -1 . CONCLUSION: The results suggest that the lipid peroxidati on in the kidneys of infrasound exposed rats can be increased and infrasound may play an important role in kidney injury.

关 键 词：次声 大鼠 肾脏 单胺氧化酶 GSH-PX SOD MDA 

分 类 号：R134.1[医药卫生—劳动卫生] TB53[医药卫生—公共卫生与预防医学]