The change in mutagenicity：study on surface water of Qiantang River due to tide  

作　　者：WuNX YangYM 

机构地区：[1]InstituteofHygiene,ZhejiangAcademyofMedicalSciences,Hangzhou310013,China

出　　处：《中国药理学与毒理学杂志》2002年第6期416-417,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：The Qiangtang River lies in Zhejiang Province of China.In this study,the genotoxicity of surface water samples from five sites along the river were detected using Ames test(TA98,TA100±S9),comet(SCGE) test and cytokinesis-block micronucleus(CBMN) tesdt(-S9) in the human peripheral lymphocytes in vitro.The results indicated that in upstream samples (first site) during falling-tide was found slight mutagenicity in TA98 strain with S9 and without S9.The mutagenicity of samples from the second to the fifth site was gradually stronger.Except the first site sample,the micronucleated cell rates of the other four samples during falling-tide significantly increased in CBMN test,and the extent of migration of DNA fragments of the four samples was found to be significantly different from control group.In the upstream(first site) samples during flow-tide were found no mutagen by three short-term tests.But the other four samples were found more stronger mutagenicity in TA98 strain with S9 than that during falling-tide.The micronucleated cell rates and the extent of migration of DNA fragments of the samples were sdignificantly high than that during falling-tide too.

关 键 词：水 诱致突变性 潮汐 钱塘江 

分 类 号：R122.12[医药卫生—环境卫生学]