Importance of blood pressure variability in organ protection in spontaneously hypertensive rats treated with combination of nitrendipine and atenolol  

血压波动性在尼群地平和阿替洛尔联合治疗自发性高血压大鼠的器官保护中的重要性(英文)

作　　者：谢和辉[1] 缪朝玉[1] 刘建国 苏定冯 

机构地区：[1]第二军医大学基础部药理学教研室,上海中国200433

出　　处：《Acta Pharmacologica Sinica》2002年第12期1199-1204,共6页中国药理学报（英文版）

基　　金：Project supported by grants 39670831 and 3007087l from the National Natural Science Foundation of China.

摘　　要：AIM: To study the importance of reduction of blood pressure variability (BPV) in the organ protection of long-term treatment with combination of nitrendipine and atenolol, which was abbreviated as Nile, in spontaneously hyperten-sive rats (SHR). METHODS: Combination of nitrendipine (10 mg·kg-1·d-1) and atenolol (20 mg·kg-1·d-1) was given in SHR chow for 12 weeks. Blood pressure (BP) was then recorded during 24 h in conscious state. After the determination of baroreflex sensitivity (BRS), rats were killed for organ-damage evaluation. RESULTS: Long-term treatment with Nile significantly decreased BP and BPV, ameliorated impaired BRS, and obviously diminished end-organ damage in SHR. The indices of left ventricular and aortic hypertrophy, and glomerulosclerosis score were all positively related to BP and BPV, and negatively related to BRS in untreated and Nile-treated SHR. Multiple-regression analysis showed that decrease in left ventricular and aortic hypertrophy was mainly related to the de-crease in systolic BPV, and amelioration in renal lesion was mainly determined by increase in BRS. CONCLUSION: Long-term treatment with Nile possessed obvious organ protection in SHR. Besides the BP reduction, the decrease in BPV and the restoration of BRS may importantly contribute to this organ protection.目的:研究降低血压波动性(BPV)在尼群地平和阿替洛尔合用对高血压大鼠的器官保护中的重要作用.方法:自发性高血压大鼠食物中给予尼群地平(10mg·kg^(-1)·d^(-1)和阿替洛尔(20 mg·kg^(-1)·d^(-1)12周.结果:尼群地平和阿替洛尔合用明显降低自发性高血压大鼠的血压和BPV,明显增高其动脉压力感受性反射敏感性(BRS),并且有效减轻其终末器官损伤.左心室肥厚指数、主动脉肥厚指数和肾小球硬化积分都与血压和 BPV呈正相关,而与 BRS呈负相关.多重回归的结果显示,左心室肥厚和主动脉肥厚减轻主要与收缩期BPV的降低相关,而肾脏损伤的改善主要决定于BRS的增高.结论:尼群地平和阿替洛尔合用长期治疗能有效减轻自发性高血压大鼠的终末器官损伤.这种保护作用除与其降低血压有关外,还与其降低BPV和增高BRS有重要关系.

关 键 词：ATENOLOL NITRENDIPINE drug combinations BAROREFLEX blood pressure blood pressure variability organ protection HYPERTENSION 

分 类 号：R96[医药卫生—药理学]