Mechanism on activation of mouse liver microsomal glutathione S—transferase—I by cyclophosphamide treatment in vivo  

作　　者：ZhenY LouYJ 

机构地区：[1]DepartmentofPharmacy,the117thHospital,Hangzhou310013,China [2]DepartmentofPharmacology＆Toxicology,CollegeofPharmaceuticalSciences,ZhejiangUniversity,Hangzhou310031,China

出　　处：《中国药理学与毒理学杂志》2002年第6期426-426,共1页Chinese Journal of Pharmacology and Toxicology

摘　　要：Membrane-associated microsomal glutathione S-transferase-I (mGST-I) is activated easily by alkyl agent or electrophilic metabolite.It was expected that toxic drugs and their metabolites derived from biotransformation by cytochrome P-450 maybe bind to and activate the mGST-I that can accelerate the metabolism of drugs to form inactive metabolites and simultaneously protect cell from damages.The aim of the present study was to investigate whether mGST-I is activated by cyclophosphamide(CP) treatment and to explore the possible mechanism in vivo.The results suggested that the main mechanism of mGST-I activation caused by overdose CP treatment is the unique sulfhydryl modification on its Cys-49.

关 键 词：环磷酰胺 谷胱甘肽转移酶 微粒体 肝 

分 类 号：R979.1[医药卫生—药品]