男性性激素与冠心病的关系  

Relationship between sex hormones and coronary artery disease in males

作　　者：费爱华[1] 刘晓红[1] 杜学亮[1] 陈书艳[1] 徐惠芬[1] 

机构地区：[1]上海第二医科大学附属新华医院心内科,上海200092

出　　处：《临床心血管病杂志》2003年第1期16-17,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究男性内源性性激素与冠心病 (CHD)之间的关系。方法 :用放射免疫法测定了 4 5例经冠状动脉造影证实有 1支以上主要冠状动脉狭窄≥ 5 0 %的男性CHD患者和 4 0例同期同年龄健康男性对照者的血清雌二醇 (E2 )、睾酮 (T)、脱氢表雄酮 (DHEA)及硫酸脱氢表雄酮 (DHEAS)的水平。结果 :①CHD组血清DHEA、DHEAS的水平明显低于对照组 (分别为P <0 .0 5 ,P <0 .0 1) ,对总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白A、B(apoA、apoB)、脂蛋白a〔Lp(a)〕、体重指数 (BMI)进行协方差分析后 ,两组差异仍有显著性意义 (分别为P <0 .0 5 ,P <0 .0 1)。②在两组中血清E2 、T、E2 /T值的水平没有明显的区别。结论 :DHEA、DHEAS水平的降低可能是男性CHD的危险因子 。Objective:To assess the relation between endogenous sex hormones and coronary artery disease (CHD) in males.Methods:Forty five male CHD documented by coronary angiography were selected as CHD group and forty normal male subjects as control.Results:Dehydroepiandrosterone(DHEA) and Dehydroepiandrosterone sulfate (DHEAS) levels were significantly lower in CHD group than those in the control group(P< 0.05 and P< 0.01 ).This association remained statistically significant even after accounting for the effects of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL C), low density lipoprotein cholesterol (LDL C), apolipoprotein A (apoA), apolipoprotein B (apoB),lipoprotein(a)〔Lp(a)〕 and body mass index (BMI). There were no significant differences in the levels of estradiol (E 2), testosterone (T), the ratio of estradiol to testosterone (E 2/T) between CHD group and control group.Conclusion:DHEA, DHEAS levels are related to CHD in males and this association in independent of the effects of several known risk factors for CHD.

关 键 词：冠状动脉疾病 性激素类 统计学处理 

分 类 号：R541.4[医药卫生—心血管疾病]