增血安胶囊的抗炎作用研究  

Studies on anti-inflammatory effects of Zengxuean Capsule

作　　者：刘俭[1] 宋洁[1] 刘振秀[2] 肖培根[1] 

机构地区：[1]中国医学科学院,协和医科大学药用植物研究所,北京100094 [2]航天医学工程研究所,北京100094

出　　处：《中成药》2003年第1期55-57,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :研究增血安胶囊 (黄芪 ,青黛 ,冬虫夏草 ,等 )在抗炎方面的药理学作用。方法 :采用巴豆油致小鼠耳廓肿胀等常规抗炎模型。结果 :增血安胶囊可明显抑制巴豆油致小鼠耳廓肿胀及角叉菜引起的大鼠足跖肿胀 ,能显著抑制二甲苯导致的小鼠腹腔毛细血管通透性增加和小鼠棉球肉芽肿的增重 ,可明显延长热刺激引起的小鼠疼痛反应的痛域值 ,并对巴豆油致摘除双侧肾上腺小鼠耳廓肿胀没有抑制作用。结论 :增血安胶囊有很强的抗炎效果 。Objective: To study the pharmacological effects of Zengxuean capsule (Radix Astragali, Indigo Naturalis, Cordyceps, etc) on anti inflammation.Methods:A few conventional models, such as the mouse pinna swelling induced by croton oil, were employed to determine the anti inflammatory activities of Zengxuean capsule.Results: Zengxuean capsule obviously inhibited the swelling of mouse pinna induced by croton oil, suppressed the edema of rat hind paw elicited by injection of 1% carrageenan, significantly depressed the increase of peritoneal capillary permeability in the xylene induced mice, and greatly decreased proliferation of granuloma led by implanting cotton pellet. It had an abatement effect of algesia induced by heat with tail flick method, and could not inhibit the swelling of pinna led by croton oil when mouse's adrenal was resected.Conclusion: Zengxuean capsule is an effective medicine on anti inflammation, and its acitivity is realized by adrenal cortical system.

关 键 词：增血安胶囊 抗炎 镇痛 中药 药理 

分 类 号：R285.5[医药卫生—中药学]