不同本底感兴趣区对显像法测定肾小球滤过率的影响  

Effect of different kind of background correction on glomerular filtration rate measured by dynamic renal imaging with ^(99m)Tc-DTPA

作　　者：尚玉琨[1] 孔令山[2] 潘文舟[2] 

机构地区：[1]第二军医大学长征医院核医学科,上海200003 [2]长海医院核医学科

出　　处：《第二军医大学学报》2003年第1期110-112,共3页Academic Journal of Second Military Medical University

摘　　要：采用 99m Tc- DTPA和 1 31 I- OIH作显像剂 ,对 132例患者行肾动态显像和肾小球滤过率 (GFR)及有效肾血浆流量(ERPF)测定。 GFR测定时 ,选用 2种本底感兴趣区 (ROI) ,即常规双肾外下方 (下本底 )和双肾内上方 (上本底 )。结果发现选用常规下本底 ROI测得肾功能较差肾的相对肾功能值能明显高于 ERPF所测 ;而选用上本底 ROI所测值更接近 ERPF所测。结果提示 99m Tc- DTPA作显像剂时 ,常规本底减除方法可能高估功能受损肾的 GFR,而采用内上方本底Dynamic renal imaging studies were performed in 132 patients using 99m Tc DTPA and 131 I OIH. Effective renal plasma flow(ERPF) and glomerular filtration rate(GFR) was obtained. GFRs were calculated with 2 background regions of interest(ROI),conventional subrenal areas(SB) and suprarenal areas(SP). The relative renal functions(RR) obtained by GFRs determination was significantly higer compared with that by ERPF. These results suggested that the RR of impaired kidney determined by GFR(SB) was obviously higher than that assessed by ERPF. Higher coefficient( r value) was gotten with GFR(SP) than with GFR(SB).Results suggested that the GFR obtained with conventional subrenal background ROI might overestimate individual renal function of the poorly functional kidney and the GFR estimated by suprarenal background ROI might be more accurate.

关 键 词：放射性核素显像 肾小球滤过率 有效肾血浆流量 本底感兴趣区 

分 类 号：R817.4[医药卫生—影像医学与核医学]