氨茶碱血药浓度与平喘疗效的关系评估  

Evaluation of the relationship between the drug blood concentration of aminophylline and its curative effect.

作　　者：陈煦艳[1] 陈晓萍[1] 徐庄剑[1] 

机构地区：[1]江苏省无锡市第四人民医院儿科,214062

出　　处：《淮海医药》2003年第1期15-16,共2页Journal of Huaihai Medicine

摘　　要：目的　观察氨茶碱治疗支气管哮喘的临床疗效与有效血药浓度之间的关系 ,指导临床合理用药。方法　给予患儿氨茶碱负荷量 3～ 4 m g/ kg静脉滴注 ,于 2 0～ 30 min内完成 ,维持量 0 .8～ 1.0 m g· kg- 1 · h- 1 。治疗后第 2天测定氨茶碱血药浓度并进行疗效判断。结果　治疗后氨茶碱平均血药浓度为 (8.80± 3.84 ) mg/ L,临床总显效率为 82 .8%。根据血药浓度将其分为 A组 (≤ 5 mg/ L )、B组 (5～ 10 mg/ L )和 C组 (10～ 2 0 m g/ L )三组。 A组和 B组、A组和 C组的临床疗效差异有非常显著性 (P<0 .0 1) ,B组和 C组的临床疗效差异无显著性 (P>0 .0 5 )。结论　氨茶碱血药浓度在 5～ 2 0 m g/ L ,能确保临床疗效并防止药物副反应的发生。Objective To observe the correlation between the drug blood concentration of aminophylline and clinical curative effect on bronchial asthma.Methods Patients received the initial dose of aminophylline 3～4 mg/kg intravenously,finished in 20～30 minutes;the maintenance dose was 0.8～1.0 mg·kg -1 ·h -1 .The drug blood concentration of amimophylline was detected on the second day of treatment.Results The average concentration of amimophylline was 8.80±3.84 mg/L,the clinical effective rate was 82.8%.According to the level of drug concentration,the patients were divided into three groups:group A(≤5 mg/L),group B(5～10 mg/L) and group C(10～20 mg/L).There were high significant differences of clinical effective rate between group A and group B,group A and group C(both P <0.01).There was no significant difference between group B and group C( P >0.05).Conclusion The drug concentration of aminophylline should be maintained in 5～20 mg/L,which could assure the clinical effect and prevent from the side effect.

关 键 词：氨茶碱 哮喘 血药浓度 药理学 

分 类 号：R562.250.5[医药卫生—呼吸系统]