活血化瘀中药对内毒素休克大鼠心脑微血管损伤的防治作用  

Prevention and treatment of activating microcirculation and removing stasis medicinal herbs on microvascular lesions of heart,brain of rats in endotoxin shock

作　　者：杨海贤[1] 赵刚[1] 于学宽[1] 沈伟[1] 郭小红[1] 曾嘉[1] 

机构地区：[1]天津医科大学电镜测试中心,天津300070

出　　处：《中国中西医结合急救杂志》2003年第1期26-28,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：天津市自然科学基金资助项目 (983 60 90 11)

摘　　要：目的 :观察活血化瘀药对内毒素休克大鼠心、脑微血管的保护作用。方法 :选择健康 Wistar大鼠(180～ 2 2 0 g) 30只 ,随机平分为正常对照组 (注射生理盐水 )、模型组〔注射脂多糖 (L PS)〕和活血化瘀 (AMRS)药物组。电镜观察心、脑微血管的超微结构变化 ,比较其变化程度。结果 :模型组的心、脑微血管内皮细胞水肿、坏死、消失 ,管腔内中性粒细胞黏附、血小板聚集、纤维素凝结。 AMRS药物组的内皮细胞超微结构接近正常 ,也未见管腔内的明显损伤。结论 :活血化瘀药物能够预防和改善内毒素休克心、脑的微血管内皮细胞损伤 ,具有明显的保护作用。Objective:To study protective effect of activating microcirculation and removing stasis medicinal herbs in the microvascular of heart,brain of rats in endotoxin shock.Methods:Thirty Wistar rats were divided randomly into three groups:control group was given normal saline (NS),endotoxin shock group was given lipopolysaccharide(LPS),and treatment group was given activating microcirculation and removing stasis(AMRS,活血化瘀) medicinal herbs.Electron microscope was used to observe the ultrastructural lesions of microvascular endothelial cells of heart,brain and different degree of lesion was compared.Results:It was revealed the remarkable changes in endotoxin shock group,that microvascular endothelial cells of the heart and brain were swelling,necrosis,and until disappear.The neutrophil adhesion,platelets aggregations,and fibrin agglutinations within the microvascular lumens.In treatment group,microvascular endothelial cells ultrastructurally tended back to normal,there were no obvious lesions in microvascular lumens as so. Conclusion: AMRS medicinal herbs appears to be able to improve and heal the damaged endothelial cells in treating endotoxin shock.

关 键 词：内毒素休克 脑微血管 活血化瘀药 内皮细胞 电镜 心微血管 

分 类 号：R285.5[医药卫生—中药学]