严重脑外伤患者血浆NO、ET、IL-6和IL-8水平变化及意义  

Change and significance of NO, ET, IL-6 and IL-8 in plasma of patients with severe brain trauma

作　　者：王伯良[1] 仲月霞[1] 曹义战[1] 陆将[1] 

机构地区：[1]中国人民解放军第四军医大学唐都医院急诊科,陕西西安710038

出　　处：《中国急救医学》2003年第2期86-87,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　观察急性颅脑损伤后患者血浆中一氧化氮 (NO)、内皮素 (ET)、白细胞介素 - 6 (IL - 6 )和白细胞介素 - 8(IL - 8)水平的变化 ,探讨它们在颅脑损伤中的作用。方法　采用Green法、放射免疫法和酶联免疫吸附法测定血浆中NO、ET、IL - 6和IL - 8水平。结果　中重型颅脑损伤患者血浆中NO、ET、IL - 6和IL - 8水平显著升高 (P <0 0 5～ 0 0 1) ,与损伤程度呈正相关。结论　NO、ET、IL - 6和IL - 8参与了急性颅脑损伤的病理生理过程。Objective To observe the change of NO, ET, IL-6 and IL-8 in plasma of patients with acute brain trauma and to explore the effects of NO, ET, IL-6 and IL-8 on brain trauma. Methods Green, RIA and ELISA were employed to detect the concentration of NO, ET, IL-6 and IL-8 in plasma. Results The plasma level of NO, ET, IL-6 and IL-8 were significantly higher in the patients with moderate and heavy brain trauma than in the patients with slight brain trauma(P<0.05～0.01), which had a positive relationship with the degree of brain trauma. Conclusion NO, ET, IL-6 and IL-8 played a role in acute brain trauma.

关 键 词：严重脑外伤 血浆 一氧化氮 内皮素 白细胞介素-6 白细胞介素-8 临床意义 

分 类 号：R651.15[医药卫生—外科学]