坐骨神经震荡伤动物模型的选择  

Establishment of animal model of sciatic nerve firearms injury in rabbits

作　　者：黄宏[1] 王贵波 王建民[1] 吴国萍[1] 李兵仓[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所第六研究室,重庆400042

出　　处：《第三军医大学学报》2003年第3期258-259,共2页Journal of Third Military Medical University

基　　金：国家重点基础研究发展规划资助项目 ("973"项目 ) (G19990 54 2 0 6 )

摘　　要：目的　建立坐骨神经火器性震荡伤模型。方法　大耳白兔 2 6只分为A、B、C、D、E组 ,以右大腿后部坐骨神经体表投影线中点为靶点 ,致伤武器为 5 3式 7 62mm滑膛枪 ,致伤弹为 0 3 8g和 1 0 3g钢珠。测钢珠致伤速度 ,计算传递能量 ,观察坐骨神经病理变化。结果　A、B、D组表现典型坐骨神经火器性震荡伤 ,C、E组损伤程度较轻 ,B组致伤速度为(93 9 8± 16 0 )m s ,传递能量 (80 0± 8 5 )J。结论　B组用 0 65g药量驱动 0 3 8g钢珠 ,既能造成典型坐骨神经震荡伤 ,动物伤情较稳定 ,符合实验要求。Objective To establish an animal model of sciatic nerve firearms injury in rabbits Methods All of 26 rabbits were divided into A, B, C, D and E groups at random The hit point was the middle point of the body surface projection of sciatic nerve in the right thigh The rabbits were injured with the type 53 musket by balls of 0 38 g and 1 03 g and with the dynamite amounts of 0 35 g, 0 65 g, and 1 20 g The injury velocity of ball was detected, and the transmission energy of steel ball was calculated The pathological changes of sciatic nerve were observed with light and electron microscopy Results In group A, B and D, typical pathological changes occurred In group B, resulting from a ball of 0 38 g and dynamite of 0 65 g, the primary velocity was (939 8±16 0) m/s, the mean transmission energy was (80 0±8 5) J Conclusion Animals inflicted with a type 53 musket with a ball of 0 38 g and dynamite of 0 65 g show typical sciatic nerve injury in a steady situation and can serve for experiment usage

关 键 词：火器伤 坐骨神经 动物模型 

分 类 号：R826.5[医药卫生—临床医学]