^(125)I诱发小鼠生殖细胞染色体畸变效应观察  

CHROMOSOMAL ABNORMALITIES INDUCED BY ^(125)I IN MOUSE GERM CELLS

作　　者：钱宏伟[1] 许荣[1] 姚凤英 

机构地区：[1]上海医科大学放射医学研究所

出　　处：《辐射研究与辐射工艺学报》1992年第2期77-80,共4页Journal of Radiation Research and Radiation Processing

摘　　要：本文选用ICR小鼠为实验动物,腹腔注射不同剂量^(125)I,研究其对小鼠生殖细胞染色体畸变发生率影响及动态变化规律。实验结果显示:(1)^(125)I染毒(555kBq)后1d染色体畸变率最高,精原细胞和精母细胞染色体畸变率均为1.8％,但畸变率随时间延长而迅速降低。(2)^(125)I染毒后1d,0、175、555及1665kEq各组精原细胞染色体畸变率分别为0.14％、0.45％、1.80％及2.65％;精母细胞染色体畸变率分别为0.13％、0.60％、1.80％及2.20％,经行列X^2检验,各组间差别均有显著意义。本文结果进一步揭示了^(125)I对哺乳动物有潜在的遗传危害。In this experiments, male of the ICR strain were used and were in- jected intraperitoneally with different dose of ^(125)I. The rate of chromosomal abnorma- lities in mouse germ cells, and its changes with time were studied. The results showed that: (1) From 1 to 28 days after injection of 555 kBq of ^(125)I, the rate of chromo- somal abnormalities of germ cells reached a peak at 1 day. During that time, the ab- normal rate in spermatogonias is 1.8%, which is cqual to that in spermatocytes. After that, the abnormal percentages in those cells were quickly droped down. (2) The ra- tes of chromosomal aberrations in spermatogonias in males treated with 0,175, 555 and 1665 kBq of ^(125)I at 1 day after injection were 0.14%, 0.45%, 1.80% and 2.65% respectively. Similarly, the chromosomal abnormal rates in spermatocytes were 0.13%, 0.60%, 1.80% and 2.20% accordingly. These results indicate ^(125)I can induce a significant increase in the percentage of chromosomal aberrations of germ cells in male treated with ^(125)I. The results also provide further evidence of the cytogenetic ef- fects to mammalian germ cells of ^(125)I.

关 键 词：生殖细胞 碘125 畸变 染毒 

分 类 号：Q345.21[生物学—遗传学]