雄性激素慢释药物的制备及其性能的研究  

PREPARATION OF SLOWLY RELEASED MALE SEX HORMONE DRUG BY RADIATION POLYMERIZATION TECHNIQUE AND ITS EVALUATION IN VIVO

作　　者：刘瑞芝[1] 雷少琼[1] 李希明[1] 汤涛[2] 陈文明[1] 方月娥[1] 董永治[1] 韩萍[1] 冯炽光 赵钢[1] 郑力[1] 

机构地区：[1]中国科学技术大学 [2]安徽省人民医院

出　　处：《辐射研究与辐射工艺学报》1992年第2期65-69,共5页Journal of Radiation Research and Radiation Processing

摘　　要：利用辐射聚合技术将雄激素丙酸睾丸酮固定在聚甲基丙烯酸β羟乙酯载体上,制备慢释放雄激素药物的方法。此种慢释药可作为睾丸的替代物,又称人工睾丸。将制得的人工睾丸植入阉割雄兔的阴囊内,定期取血,用放射免疫法测定血清睾酮水平。结果表明人工睾丸可在动物体内稳定地释放丙酸睾丸酮,并使血清睾酮维持在429±36ng/100ml水平。植入部位周围组织切片观察未见异常,证明人工睾丸具有较好的组织相容性。The radiation polymerization technique was used for immobilization testosterone propionate into crosslinked network of polyhydroxyethyl methacrylate to prepare slowly released male sex hormone drug which is used for testicular prosthesis. The testicular prosthesis was transplanted into the scrotum of male rabbit whose tes- tes was excised 2 months before the transplantation. Then the level of male sex hor- mone in serum was measured by radioimmunoassay once a week after transplantation. The results of measurement in a period of 6 months were shown that the testicular prosthesis has a stable release of male sex hormone. The testosterone level in serum of the castrated male rabbits rises markedly and finally stablizes at the level of 429± 36ng/100 ml after transplantation. Mircoscopic txamination of biopsies taken from the tissues around the testicular rrosthesis showcd that tissue compatibility was revea- led well.

关 键 词：辐射聚合 人工睾丸 雄激素 慢释药 

分 类 号：TQ467.92[化学工程—制药化工]