肝康栓对于慢性乙型肝炎的临床疗效  

The Effects and Side Effects of Suppository Gankang on Chronic HBV Infection

作　　者：杨道锋[1] 田德英[1] 沈汉馨[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《中西医结合肝病杂志》2002年第5期270-271,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察自制制剂肝康检对慢性HBV感染的临床疗效和不良反应。方法:279例HBV感染者根据肝功能是否正常分两组,给予肝康栓治疗,肝功能异常组以甘利欣胶囊为对照,观察疗效和不良反应。结果:在肝功能异常组,肝康检对患者临床症状、体征的缓解率和肝功能恢复的治疗效果与甘利欣相近,但对HBsAg、HBeAg和HBV DNA的阴转率明显高于甘利欣。在肝功能正常组,肝康栓治疗6个月后HBsAg、HBeAg和HBV DNA的阴转率分别为12.5%、36.5％、39.1％。所有治疗病例未见严重不良反应。结论:肝康栓对慢性HBV感染具有较好的疗效,不良反应轻微。Objective: To evaluate the efects and side effects of suppository Gangkan (SGK) on chronic HBV infection. Methods: Two hundred and seventy-nine cases with chronic HBV infection were divided into 2 groups. One hundred and seven cases with chronic hepatitis B whose ALT were over 80U/L (group A) were treated by SGK twice a day for 6 months , and other 40 cases having similar feature were employed to receive diammonia glycyrrhizinate therapy as a control for group A. 176 chuonic HBV infected cases whose ALT was normal (group B) were administered SGK twice a day for 6 months. The effect and side effect were observed. Results: In group A, SGK showed the same effect for relieving the symptoms and signs as diammonia glycyrrhizinate, but showed a better effect for loss of HBeAg and HBV DNA. In group B, the loss rates of HBeAg and HBV DNA were 12.5% , 36.5% and 39.1% , respectively. No severe side effect appears in all of subjects. Conclusion: SGK has a positive effect for chronic HBV infection and a mild side effect.

关 键 词：肝康栓 慢性乙型肝炎 不良反应 临床疗效 

分 类 号：R512.6[医药卫生—内科学]