氯化镓治疗去卵巢大鼠骨质疏松的实验观察  

Preliminary study on the anti-osteoporotic effect of gallium in ovariectomized female rats

作　　者：王治伦[1] 邸明芝[1] 

机构地区：[1]西安交通大学医学院地方病研究所,陕西西安710061

出　　处：《中国地方病学杂志》2002年第6期439-441,共3页Chinese Jouranl of Endemiology

摘　　要：目的　探讨镓对去卵巢大鼠骨质疏松的治疗作用。方法　通过切除大鼠卵巢建立骨质疏松模型 ,经氯化镓治疗 12周后 ,用单光子法测量骨密度 ;放免法检测相关血清学指标 ;测定骨病理形态学指标。结果　氯化镓治疗组血清抗酒石酸酸性磷酸酶、骨小梁间距低于骨质疏松对照组 ,而骨密度和骨小梁宽度高于骨质疏松对照组。Objective To observe the anti osteoporotic effect of gallium chloride in ovariectomized female rats.Methods Osteoporotic models of rats were duplicated by ovariectomy. Rats in therapeutic groups were administered gallium chloride, after a period of 12 weels, parameters of blood and bone were obtained.Results Compared to the osteoporosis control group,there was a significantly decreased level of blood tartrate resistant acid phosphatase and space between trabecula bones in the gallium group.Meanwhile,the bone minera density was higher and trabecular bones were wider than that of osteoporosis control group significantly (P<0.05).Conclusions Gallium chloride can improve osteoporosis in ovariectomized female rats.

关 键 词：大鼠 骨质疏松 实验 氯化镓 治疗 

分 类 号：R58[医药卫生—内分泌]