血脉宁颗粒制备工艺研究  

STUDY ON THE PREPARATION PROCESS OF XUE MAI NING GRANULE

作　　者：唐灿[1] 尹思源[1] 蒲清荣[1] 赵剑[1] 

机构地区：[1]泸州医学院附属第二医院制剂中心,四川泸州646000

出　　处：《泸州医学院学报》2002年第5期396-399,共4页Journal of Luzhou Medical College

基　　金：四川省教育厅 2 0 0 0年重点项目 (2 0 0 0 -A30 )

摘　　要：目的 :优选血脉宁颗粒制备工艺。方法 :以黄芪甲苷收率为指标 ,应用正交设计试验优选血脉宁颗粒提取工艺。结果 :影响乙醇渗漉提取的主次因素 :A >B >C(A为乙醇加入量 ;B为提取时间 ;C为乙醇浓度 ) ,优选的提取工艺条件 :乙醇加入量为药材量的 4 8倍 ,乙醇浓度 80 % ,提取 2 4h ;优选的沸腾制粒工艺条件为 :稠浸膏 :糊精=1 5∶1,稠浸膏相对密度为 1 2 0 ,喷液电压为 80伏特 ,每批料抖袋 6 5个周期 (每个抖袋周期来回抖袋 2次 )。结论Objective: To optimize the preparation process of XueMaiNing Granule. Methods: By the orthogonal design, taking the gain rate of Astragaloside IV as the index, the preparation process condition of XueMaiNing Granule was optimized. Results: The factors influencing the alcohol-percolation were as follows: A>B>C (A: the amount of alcohol added. B: the percolation time.C:the alcohol concentration). The optimum percolation condition obtained was: 48-fold of 80% alcohol, being added and percolating for 24 hours. The optimum conditions of granulation by sprayer were that the fluid extract was 1.5 times of Dextrin in weight; the relative density of the fluid extract was 1.20(measured at 25℃), the voltage of sprayer was 80 volts, the period of bag shaking was 65 (shaking bag back and forth twice in each period). Conclusion: The results of the experiment show that the preparation process of XueMaiNing Granule is stable and applicable.

关 键 词：血脉宁颗粒 正交设计试验 制备工艺 中药制剂 黄芪甲苷 提取工艺 

分 类 号：R284.2[医药卫生—中药学] R283[医药卫生—中医学]