沙漠行军血浆热休克蛋白与热应激的关系  

Study on relation between heat shock proteins and heat stress of marcher in desert

作　　者：刘兵[1] 邬堂春[2] 徐文[1] 陈胜[2] 张雪玲[1] 吴志豪[1] 

机构地区：[1]兰州军区联勤部军事医学研究所,兰州730020 [2]同济医科大学职业医学研究所

出　　处：《中国公共卫生》2003年第2期139-140,共2页Chinese Journal of Public Health

基　　金：全国青年科学基金 (97Q0 2 2 )

摘　　要：目的　探讨沙漠干热环境徒手应激行军者热休克蛋白 (HSP2 7)与机体热应激的关系。方法　对在沙漠干热环境中分别以 3 5km/h和 5 0km/h速度徒手行军 1,2 ,3h的 5 6名战士和 14名对照血浆HSP70和HSP2 7、心律增值、肛温增值和积热指数等进行了研究。结果　不论是 3 5km/h还是 5 0km/h徒手行军 ,各行军时间组HSP70与对照组 ,各行军时间组间均无显著性差异 ;各行军时间组HSP2 7明显高于对照组 (P <0 0 5 ) ,各行军时间组间HSP2 7均无显著性差异 ;各行军时间组心率增值、肛温增值和积热指数均与对照有显著性差异 (P <0 0 5 ) ;3 5km/h行军 3h组心率增值明显高于行军 2h组 (P <0 0 5 ) ,5 0km/h行军 2 ,3h组积热指数明显高于行军 1h组 (P <0 0 5 ) ,行军 3h组明显低于行军 2h组 (P <0 0 5 )。结论　沙漠干热环境徒手应激行军者血浆HSP2 7与热应激密切相关 ,HSP70与热应激关系不大 ;沙漠热环境热适应锻炼以 5 0km/h行军Objective To explore the relation between heat shock proteins and heat stress of marchers without load in dry-heat desert.Methods The plasma HSP70 and HSP27,heart beat,rectal temperature and body heat storage index(BHSI) of 56 marchers and 14 controls were detected.Results Either at the speed of 3.5 km/h or 5.0 km/h,the plasma HSP27 in the marching groups were much more than the control(P<0.05);and the plasma HSP70 in the marching groups were slightly over the control(P>0.05);the heart beat in marching groups were more than the control(P<0.05).BHSIs were much more than the control except that marching for 1 hour at 5.0 km/h.Conclusion There was a close relation between HSP27 and heat stress,and no relation between HSP70 and heat stress without load in dry-heat desert.Therefore,the plasma HSP27 was better than HSP70 in the monitor of heat stress.It was the optimum acclimatization to heat that people march for 2 hours at 5.0 km/h in dry-heat desert.

关 键 词：干热 沙漠 热休克蛋白 应激行军 热应激 行军 

分 类 号：R339.53[医药卫生—人体生理学]