薄荷脑和冰片对长春西汀的促渗作用  

Effects of 1-menthol and borneol on the percutaneous absorption of vinpocetine

作　　者：李华[1] 林建阳[2] 李嘉煜[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药剂教研室,沈阳110016 [2]中国医科大学第一临床学院临床药理教研室,沈阳110001

出　　处：《中国新药杂志》2003年第1期34-36,共3页Chinese Journal of New Drugs

摘　　要：目的 :采用大鼠腹部皮肤研究薄荷脑及冰片在不同溶剂中对长春西汀体外经皮渗透的影响。方法 :采用Valia Chien水平扩散池 ,研究长春西汀经大鼠腹部皮肤的渗透性。半池有效扩散面积为 1 .91cm2 ,按规定时间取样 ,采用高效液相色谱法进行测定 ,进样量为 2 0 μL ,计算药物经皮渗透动力学参数。 结果 :薄荷脑与冰片均能促进长春西汀经皮渗透 ,在不同的溶剂中 ,其发挥的促渗作用也不同。丙二醇为溶媒时 ,它们的促渗作用不佳 ,而以乙醇为溶媒时 ,3 %薄荷脑 40 %乙醇 水与 5 %薄荷脑 40 %乙醇 水复合系统均能显著地促进长春西汀经皮渗透 ,增渗比分别为 7.0 5与 7.1 8。结论Objective:To study the effects of l menthol and borneol dissolved in various solvents on the transdermal absorption of vinpocetine.Methods:The penetration rate of vinpocetine through rat skin in vitro was measured using Valia Chien diffusion cell with an effective diffusional area of 1.91 cm 2.20μL samples were withdrawn from the receptor solution over 10h and assayed by HPLC method.Results:Both l menthol and borneol had different effects on the transdermal absorption of vinpocetine.The permeation flux of enhancers in propylene glycol was lower than that in ethanol.3% l menthol 40% ethanol water and 5%l menthol 40% ethanol water had strong effects on the permeation of vinpocetine with the ER value of 7.05 and 7.18.Conclusion:l menthol and borneol dissolved in various solvents may enhance the percutaneous absorption of vinpocetine.

关 键 词：透皮吸收 促渗剂 长春西汀 薄荷脑 冰片 

分 类 号：R971.1[医药卫生—药品]