1-苄基-4-哌啶酮的合成工艺改进  

Research on Synthetic Process of 1-Benzyl-4-piperidones

作　　者：陆文超[1] 李瑛琦[2] 郭春[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《辽宁化工》2003年第1期1-2,共2页Liaoning Chemical Industry

摘　　要：以苄胺和丙烯酸甲酯为起始原料 ,合成OPC -2 1 2 68的重要中间体 1 -苄基 -4 -哌啶酮 ,并对每步反应的工艺进行优化 ,确定了最佳反应条件 ,三步反应的总收率为 74 .5 % ,比文献值提高了1 4 .5 %。新工艺做法简单 ,成本降低 。Benzyl-4-piperidones, one of the important mid-body of OPC-21268, was synthesized from benzylamine and methyl acrylate. Process of every reaction was optimized, and the best condition of reaction was defined. The total yield of three reactions was 74.5%, which was 14.5% more than the yield reported in literature. The new process was fit to industry production for its easy method and low costs.

关 键 词：1-苄基-4-哌啶酮 合成工艺 改进 苄胺 

分 类 号：TQ253[化学工程—有机化工]