用溴化铜代替液溴合成对甲氧基-α-溴代苯乙酮  

Synthesis of p-Methoxy-α-Bromoacetophenone by Substituting Cupric Bromide for Liquid Bromine

作　　者：彭安顺[1] 王立斌[1] 

机构地区：[1]临沂师范学院,山东临沂276005

出　　处：《辽宁化工》2003年第1期17-18,共2页Liaoning Chemical Industry

摘　　要：以对甲氧基苯乙酮和溴化铜为原料 ,用乙酸乙酯和氯仿的混合液作反应介质合成了对甲氧基 α 溴代苯乙酮。考察了影响溴代收率的因素 ,最佳合成条件为 :溴化铜∶对甲氧基苯乙酮 (摩尔比 )为 2 2∶1 ,反应在回流温度下进行 ,回流时间 2 0h,收率可达 89 4 %。p-Methoxy-α-bromoacetophenone was synthesized with p-methoxyacetophenone and cupric bromide as raw materials and the mixture of ethyl acetate and chloroform as reactions mediation.The factors that had influence on the substitution reaction were investigated.The optimum reaction conditions were as follow:ratio of cupric bromide to p-methoxyacetophenone was 2.2mol∶1mol,reaction temperature was reflux temperature and reflux time was 2.0 h. The yield under the optimum reaction conditions was up to 89.4 %.

关 键 词：溴化酮 代替 液溴 合成 对甲氧基-Α-溴代苯乙酮 对甲氧基苯乙酮 

分 类 号：TQ244.4[化学工程—有机化工]