β-K_4H_3[SiW_9O_(37)(CpTi)_3]·11H_2O环戊二烯钛多酸衍生物与DNA作用研究  

Investigation on the Interaction of β-K_4H_3 [SiW_9O_(37)(CpTi)_3]·11H_2O Polyacid Derivative with DNA

作　　者：李建新[1] 王英[2] 王晓红[1] 刘巨涛[1] 李玉新[2] 黄百渠[2] 刘景福[1] 

机构地区：[1]东北师范大学化学学院 [2]东北师范大学遗传与细胞研究所,长春130024

出　　处：《高等学校化学学报》2003年第2期214-215,共2页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :39970 82 4)资助

摘　　要：The interaction between β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K 4H 3[SiW 9O 37(CpTi) 3]·11H 2O can degrade the genomic DNA. The treatment of plasmid DNA with β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis . These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.The interaction between β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K 4H 3[SiW 9O 37(CpTi) 3]·11H 2O can degrade the genomic DNA. The treatment of plasmid DNA with β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis . These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.

关 键 词：环戊二烯钛 多酸衍生物 DNA β-K4H3[SiW9O37(CpTi)3]·11H2O 琼脂糖凝胶电泳 药物设计 构象 抗肿瘤药物 抗肿瘤活性 切割作用 

分 类 号：R979.1[医药卫生—药品] R914.2[医药卫生—药学]