良恶性腹水染色体诊断标准和检查方法的探讨  

Approach to the Diagnostic Standards and Method on Chromosome Analysis of Malignant or Benign Ascites

作　　者：张文璇[1] 陈玉丽[2] 陈国枢 

机构地区：[1]福建医学院基础外科研究室 [2]福建医学院附属第一医院内科

出　　处：《福建医学院学报》1992年第4期308-310,共3页

摘　　要：对已确诊的良恶性腹水患者各32例进行染色体检查。结果恶性腹水中阳性率84.4％,准确率90％。良性腹水中1例误诊为恶性,误诊率3.1％。作者认为在20个中期分裂相中有3个以上细胞存在超二倍体和(或)染色体结构畸变可作为恶性腹水的诊断标准,并认为分裂相多、染色体数目的波动范围大、间期细胞核直径大小悬殊、成堆异形胞核及多核仁细胞出现等亦可作为辅助诊断指标。Malignant ascites from 32 patients and benign effusions from 32 cases were amined by chromo- some analysis. The positive rate was 84. 4% and the corrective rate was 90% in effusions from cancer patients. Only one of benign effusions was misclassified as malignant. Error rate was 3. 1%. With regard to the standards for the diagnosis of malignant ascites by chromosome analysis, we suggest that 20 apparently intact mitoses should be examined. If presence of three or more abnorma cells (hyper- diploid) and/or containing constitution of chromosomal aberration is regarded as the minimum criterion for the diagnosis of malignant neoplasm. We are of the opinion that finding many metaphases, extensive range of the chromosome number and diameter of the neuclei, heteromophous massed neuclei and polynucleolar cells in effusions might be the probable indications of malignancy.

关 键 词：腹水 染色体 诊断 

分 类 号：R442.504[医药卫生—诊断学]