定量门控^(99m)Tc-MIBI心肌显像测量左室功能的临床应用  

Clinical study on quantification of left ventricular function by gated myocardial perfusion SPECT with ^(99m)Tc-MIBI

作　　者：吴秋莲[1] 徐浩[2] 

机构地区：[1]暨南大学医学院护理系内科,广州510632 [2]暨南大学医学院第一附属医院核医学科,广州510632

出　　处：《广东医学》2003年第2期131-133,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目 (编号 :99M0 4 60 4G);广东省医药卫生科学研究基金资助项目 (编号 :A2 0 0 2 32 0 )

摘　　要：目的　探讨定量门控 99mTc -MIBI心肌显像测量左室功能的临床价值。方法　对 3 5例不同左室功能受试者同时进行定量门控 99mTc -MIBI心肌显像 (QGSPECT)和门控心血池显像 ,以比较两种方法测量左室功能的相关性。选择 85例患冠心病 (CAD)风险概率极低 (<10 % )的受试者 ,建立QGSPECT测量静息左室射血分数 (LVEF)正常参考值。结果　QGSPECT测量 3 5例不同左室功能受试者的静息左室功能参数LVEF(r =0 90 )、EDV(r =0 94)、ESV(r =0 97)分别与静息门控心血池显像计算的结果呈显著正相关 (P <0 0 1)。QGSPECT测量的 85例受试者的静息LVEF测量值呈正态分布 ,其正常参考值为≥ 45 %。结论　QGSPECT能准确地评价左室功能 ,有较大的临床实用价值。Objective To evaluate the clinical value of quantification of left ventricular (LV) function by gated myocardial perfusion SPECT with 99m Tc-MIBI . Methods Gated myocardial perfusion SPECT with 99m Tc-MIBI (QGSPECT) and gated blood pool imaging were performed in 35 individuals with different LV function. The LV functional parameters(LVEF, EDV and ESV) were calculated using SPECT processing software. QGSPECT was performed on 85 patients with a low Bayesian likelihood(<10%) of coronary artery disease. The normal limit of resting LVEF values was evaluated. Results The correlation between rest QGSPECT and rest gated blood pool imaging was: r =0 90 for LVEF( P <0 01), 0 94 for EDV ( P <0 01) and 0 97 for ESV( P <0 01). The distribution of resting LVEF values was gaussian( P >0 05). The normal limit was LVEF≥45% in 99m Tc-MIBI . Conclusion Quantification of LV function can be accurately evaluated using gated myocardial perfusion SPECT with 99m Tc-MIBI .

关 键 词：定量门控 ^99MTC-MIBI 心肌显像 测量 左室功能 临床应用 

分 类 号：R817.42[医药卫生—影像医学与核医学]