改变枸橼酸和EDTA抗衡阳离子对草酸钙结石抑制作用的体外模拟  

In Vitro Simulation on the Inhibition of Calcium Oxalate Calculus by Changing the Counterions of Citric Acid and EDTA

作　　者：欧阳健明[1] 谭燕华[1] 邝荔 苏泽轩[3] 粱蔚波[1,2] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所 [2]暨南大学医学院第一附属医院泌尿外科,广州510632 [3]暨南大学医学院第一附属医院泌尿外科

出　　处：《无机化学学报》2003年第3期312-316,共5页Chinese Journal of Inorganic Chemistry

基　　金：广东省自然科学基金重点项目(No.013202);国家自然科学基金资助项目(No.20031010);教育部重点科学技术项目(No.1998-121);广东省重点攻关项目(No.C31401-2001);广州市重点科技项目(No.SZ-613-2001)。

摘　　要：The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate(CaO x )were in-vestigated in silica gel with a doubl e diffusion technique.The ability o f inhibiting the growth and aggregation of CaO x crystal and the ability of inducing f ormation of COD follows:potassium c itratesodium citrate >citric acid.Na 2 EDTA had a stronger ability to inhibi t the aggregation of CaO x crystals than that of EDTA,but a weak er ability to inhibit nucleation and growth of C aO x crystals.Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD,t hat is,COD is easy to be expelled from the body along with the urine.So both inducing formation of COD and in hibiting growth and aggregation of CaO x crystal can decrease the probability of urinary stones.These results hav e positive significance in the prevention and cure of urinary stones clin ically.The effects of counterions of citric acid and EDTA on the crystallization of calcium oxalate (CaOx) were investigated in silica gel with a double diffusion technique. The ability of inhibiting the growth and aggregation of CaOx crystal and the ability of inducing formation of COD follows: potassium citrate much greater than sodium citrate > citric acid. Na(2)EDTA had a stronger ability to inhibit the aggregation of CaOx crystals than that of EDTA, but a weaker ability to inhibit nucleation and growth of CaOx crystals. Since COM exhibits a greater degree of attachment to renal tubule cells in culture compared with COD, that is, COD is easy to be expelled from the body along with the urine. So inducing formation of COD and inhibiting growth and aggregation of CaOx crystal can decrease the probability of urinary stones. These results have positive significance in the prevention and cure of urinary stones clinically.

关 键 词：草酸钙结石 枸橼酸 EDTA 抗衡离子 凝胶 

分 类 号：O614.231[理学—无机化学] O648.17[理学—化学]