小儿局灶节段性肾小球硬化53例临床病理分析  

Clinicopathological analysis of focal and segmental golmerulosclerosis in children:A report of 53 cases

作　　者：吴湘如[1] 卫敏江[2] 张忠德[1] 储谦[3] 张凤英[1] 殷敏智[1] 

机构地区：[1]上海第二医科大学附属新华医院病理科,上海200092 [2]上海第二医科大学附属新华医院小儿肾内科,上海200092 [3]上海第二医科大学附属瑞金医院病理科,上海200025

出　　处：《临床与实验病理学杂志》2002年第6期585-587,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :探讨小儿局灶节段性肾小球硬化 (FSGS)的病理特点及发病机制。方法 :对 5 3例肾穿标本进行光镜、电镜及免疫荧光检测。结果 :肾小球局灶节段性透明变性及间质泡沫细胞浸润在小儿原发性FSGS中是一个较为特征性的表现。原发性FSGS中 ,尖端病变一型预后良好。一部分轻微病变患者可能发展为FSGS。出现继发性FSGS则是预后不良的表示。结论 :区别原发性还是继发性FSGS对临床治疗。Purpose To study the pathological characteristics of focal and segmental glomerulosclerosis (FSGS) and its pathogenesis. Methods Fifty three samples of kidney biopsy in children were examined by microscopy, electron microscope and immunofluorescence. Results Focal segmental hyalinosis and intraglomerular foamy cells were characteristic of primary into FSGS for children. The tip lesion had a better prognosis in the primary FSGS. Some minimal changes could developed into FSGS subsequently. The appearance of the secondary FSGS had a poor prognosis for glomerulonephritis. Conclusion It is very important for treatment and prognosis to differentiate the primary and secondary FSGS.

关 键 词：肾小球硬化症 病灶性 儿童 病理学 临床 显微镜检查 电子 

分 类 号：R692.32[医药卫生—泌尿科学]