促炎细胞因子在慢性鼻窦炎发病中的作用  

The effect of proinflammatory cytokines in pathogenesis of chronic sinusitis

作　　者：李延忠[1] 房振胜[2] 杜志华[2] 赵文波[2] 

机构地区：[1]山东大学卫生部耳鼻咽喉科学重点实验室,济南250012 [2]泰山医学院附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2003年第2期68-70,T002,共4页Journal of Clinical Otorhinolaryngology

基　　金：山东省卫生厅青年科学研究基金资助项目(No .1998CA2CDA1)

摘　　要：目的 :探讨促炎细胞因子在慢性鼻窦炎发病机制中的作用。方法 :应用免疫组化SABC法对两型慢性鼻窦炎上颌窦粘膜内白细胞介素 1, 8(IL 1,IL 8)和肿瘤坏死因子 (TNF)进行检测。结果 :在慢性单纯性鼻窦炎Ⅰ型组中IL 1、IL 8和TNF阳性细胞数明显高于对照组 (P <0 .0 1) ,而Ⅱ型组中IL 8和TNF阳性细胞数明显高于对照组 (P <0 .0 1) ;Ⅰ型组IL 1明显高于Ⅱ型组 (P <0 .0 1) ;另两类细胞因子在两组间差异无显著性意义。结论 :促炎细胞因子在慢性鼻窦炎发病中起一定作用 ,但两型鼻窦炎起作用的细胞因子并不相同 。Objective:To investigate the effect of the proinflammatory cytokines, including IL 1, IL 8 and TNF in the pathogenesis of chronic sinusitis.Method:Using immunohistochemical streptavidin biotin peroxidae complex (SABC) method to investigate the expression of interleukin 1(IL 1), IL 8 and tumor necrosis factor (TNF) in the local mucosa of the two type chronic sinusitis.Result:There were significantly large numbers of IL 1+ ,IL 8+ and TNF+ cell in chronic sinusitis type Ⅰ compared with healthy control (P< 0.01 ). The numbers of IL 8+ and TNF+ cell in the chronic sinusitis type Ⅱ were significantly larger than that in the healthy control (P< 0.01 ). The numbers of IL 1+ cell in chronic sinusitis type Ⅰwere significantly larger than that in chronic sinusitis type Ⅱ(P< 0.01 ).Conclusion:This study indicates that proinflammatory cytokines may play an important role in the pathogenesis of chronic sinusitis. It appears that specific cytokine patterns are found in different forms of sinusitis. The investigation of different cytokine patterns may help to understand the different pathogenesis in chronic sinusitis subgroups.

关 键 词：鼻窦炎 慢性 白细胞介素-1 白细胞介素-8 肿瘤坏死因子 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]