均匀设计法筛选诺氟沙星锌颗粒的处方  

Screening the Formulae of Norfloxacin Zinc Granules Using Uniform Design

作　　者：王胜浩[1] 林芳[1] 左军斌[1] 

机构地区：[1]浙江省医学科学院药物研究所,杭州市310013

出　　处：《中国药房》2003年第2期79-80,共2页China Pharmacy

摘　　要：目的 :以均匀设计法筛选诺氟沙星锌 (NF -Zn)颗粒的处方。方法 :采用U5(54)试验表 ,设计5种颗粒处方 ,分别考察各处方的沉降速率、粒度、溶化性、颗粒水分、口感。结果 :经计算机多元回归分析 ,筛选得到的最佳处方为每包含主药0 2g、羧甲基淀粉钠0 25g、2 %PVP适量、甘露醇0 55g。结论 :均匀设计法筛选水不溶性的NF -Zn颗粒处方 ,方便、快捷。OBJECTIVE:To screen the formulae of norfloxacin zinc(NF-Zn) suspended granules using uniform design METHODS:The uniform design with 5 levels and 4 factors was employed to screen five formulae of NF-Zn and sedimentation rate,granularity,dissolubility,moisture content and taste of these granules were evaluated and scored The total score of each formula was regressed with the 4 factors by computer RESULTS:The results of regression equation suggested that the optimum formula was NF-Zn 0 2g,CMS-Na 0 25g,2%PVP and manitol 0 55g in each packet CONCLUSION:It is effective and convenient to optimize the formula of NF-Zn granules by uniform design

关 键 词：均匀设计法 颗粒 诺氟沙星锌 处方 

分 类 号：R451[医药卫生—治疗学]