盐酸纳洛酮(金尔伦)治疗急性颅脑损伤25例疗效观察  

Clinical Study on Naloxone in Treatment of 25 Patients With Acute Craniocerebral Trauma

作　　者：黄志雄[1] 邓英[1] 关国梁[1] 林启明[1] 张俊芳[1] 

机构地区：[1]广东省南海市人民医院,南海市528200

出　　处：《中国药房》2003年第2期98-100,共3页China Pharmacy

基　　金：广东省医学科研基金资助项目(A2000751)

摘　　要：目的 :探讨早期应用盐酸纳洛酮 (金尔伦 )对急性颅脑损伤的临床疗效。方法 :对入选的46例急性颅脑损伤患者在常规治疗的基础上 ,随机分为两组 ,治疗组25例 ,用金尔伦治疗 ,每天8mg,以21例同等伤情未用金尔伦药物治疗病例为对照组 ,于用药1天、7天后观察GCS评分、血内皮素水平、经颅多谱勒、脑电图的变化情况 ,对照组及治疗组结果均进行统计学分析。结果 :金尔伦治疗组GCS评分明显升高 ,血内皮素水平下降 ,脑血管痉挛发生率及脑电波异常率显著下降 ,各项指标均明显优于对照组 (P<0 05)。结论 :早期应用金尔伦能有效改善急性脑外伤患者的临床症状 ,减轻脑血管痉挛 ,降低伤残率 ,促进神经功能恢复 ,改善预后 。OBJECTIVE:To study the therapeutic effect of naloxone early to administer on acute craniocerebral trauma ME_THODS:46 patients with acute craniocerebral trauma were randomly divided into two groups:Besides routine treatment,25 patients were treated with naloxone in a dose of 8mg q d ,21 patients did not treated with naloxone The GCS score,plasma ET levels,transcranial Doppler(TCD),and electroencephalogram(EEG) were measured 1 day,7 days after the administration The results were analyzed statistically RESULTS:In treatment group,GCS score was obviously improved,the level of ET in plasma was reduced;brain vasospasm incidence rate was lower and abnormal rate of EEG was lower in comparison with those in control group As a result,the detecting indices in treating group were superior to those in the control group(P<0 05) CONCLUSI_ON:Naloxone early to administer may improve the consciousness,reduce brain vasospasm,decrease disability rate and improve living quality in the moderate and severe craniocerebral trauma

关 键 词：盐酸纳洛酮 颅脑损伤 内皮素 脑超声描记术 脑电描记术 

分 类 号：R651.15[医药卫生—外科学]