左旋四氢巴马汀对大鼠血清中催乳素水平的影响  

Effect of L-tetrahydropalmatine on Rat Serum Prolaction

作　　者：郑晓鹤[1] 尤春来[1] 景宏[1] 刘峰[1] 

机构地区：[1]辽宁中医学院中药药理教研室,辽宁沈阳110032

出　　处：《辽宁中医学院学报》2003年第1期54-55,共2页Journal of Liaoning College of Traditional Chinese Medicine

摘　　要：目的 :观察左旋四氢巴马汀 (L tetrahydropalmatine,L THP)对血清催乳素 (prolactionPRL)水平的影响 ,研究L THP的中枢多巴胺受体阻断作用。方法 :成熟雌性大鼠腹腔注射 (ip)多巴胺受体激动剂、拮抗剂或L THP后 ,颈动脉采血 ,然后用放射免疫法测定血清中的催乳素水平。结果 :L THP引起血清PRL水平迅速而显著的增加 ,效应持久 ,具有剂量依赖性。ipL THP(10mg·kg-1)就可显著拮抗培高利特 (Pergolide ,Per)诱导的大鼠血清PRL水平低下的作用 ,并随剂量的增大而增强。结论 :L THP可能是D2 受体阻断药。Objective: Effects of L tetrahydropalmatine(L THP)on rat serum prolaction(PRL) and antagomism of L THP on dapamine(DA)were studied. Method :Injection of DA receptor agonist,blocker or L THP in mature female rats.Sampling blood from rat carotid.PRL levels were detected by radioimmunoassay. Result: L THP significantly and rapidly increased PRL level and effected durably and dose dependently.L THP(10mg·kg -1 ,ip)significantly blocked decrease of rat serum PRL caused by Pergolide(Per 10mg·kg -1 ,ip)and effected dose dependently. Conclusions: L THP was probable Dopamine D 2 receptor antagonist.

关 键 词：左旋四氢巴马汀 催乳素 放射免疫法 D2受体 培高利特 

分 类 号：R285.5[医药卫生—中药学]