消糖灵片对糖尿病模型大鼠降血糖作用的实验研究  

Experimental Study on Effect of Xiao Tang Ling Tablet on Reducing Blood Sugar of Rats with Diabetes

作　　者：何学斌[1] 李少兰[2] 谈运良 曾伶[1] 吴耀[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院老研所,湖北武汉430077 [2]武汉市中医院,湖北武汉430015 [3]武汉茗实药业生物有限责任公司,湖北武汉430079

出　　处：《辽宁中医学院学报》2003年第1期56-57,共2页Journal of Liaoning College of Traditional Chinese Medicine

摘　　要：目的 :观察消糖灵片 (XTLP)对实验性糖尿病大鼠降低血糖值的作用。方法 :将 5 0只糖尿病模型鼠(四氧嘧啶造模 )随机分为模型组 ,消糖灵片组 (低、中、高剂量 )和D86 0组 ,模型组灌胃生理盐水 2 0mg/kg·d-1;消糖灵片组 (低、中、高剂量 )分别灌胃XDLP 0 6 9g/kg·d-1、1 37g/kg·d-1和 2 74 g/kg·d-1,D86 0组灌胃剂量为0 1g/kg·d-1,容量均为 2 0ml/kg·d-1,每日 1次 ,连续 10d。禁食 12h后 ,第 11d取血 ,测定大鼠空腹血糖值和胆固醇含量。结果 :与治疗前 (造模后 )比较 ,消糖灵片组 (低、中、高剂量 )大鼠血糖值均降低 (P <0 0 5～ 0 0 1) ;与模型组比较 ,中、高剂量组亦有显著性差异 (P <0 0 5 ) ;与治疗前 (造模后 )比较 ,消糖灵片组 (低、中、高剂量 )血清胆固醇含量明显降低 (P <0 0 5 ) ,而D86 0对胆固醇含量无明显影响 (P >0 0 5 )。结论 :消糖灵片对化学性糖尿病模型大鼠有明显的降低血糖值和血清胆固醇含量的作用 ,而对正常大鼠血糖值水平无明显影响。Objective: To observe the reducing effect of xiao Tang Ling Pian(XTLP)on blood sugar(BS)of experimental rats with diabetes. Methods: 50 rats with diabetes model(model was set up through alloxan)were randomly divided into model group,XTLP group(low,middle,and high dose)and D860 group.Rats in model group were fed by salline(20mg/kg·d -1 ).Rats in XTLP group(low,middle,and high dose)were fed by XTLP(0 69g/kg·d -1 ,1 37g/kg·d -1 and 2 74g/kg·d -1 ,respectively),Rats in D860 group were fed by D860(0 1g/kg·d -1 ),The therapeutic volumes of all group were 20ml/kg,once a day for 20 days.After stopping feed 12 hours,the levels of BS and cholesterol(CH) in rats were measured. Results: Compared to before of therapy(after model was set up),The levels of BS of rats in XTLP group(low,middle,and high dose)reduced obviously( P<0 05 or P<0 01), Compared to model group,The levels of BS of rats in XTLP group(low,middle,and high dose) have also significantly difference( P <0 05),Compared to before of therapy,the levels of serum CH of rats in XTLP group(low,middle,and high)have reduced obviously( P <0 05),but D860 has not effect on level of CH in rats( P >0 05). Conclusion: XTLT has reduced obviously levels of BS and CH in rats with chemistry diabetes model,but it can not effect on level BS in normal rats.

关 键 词：消糖灵片 糖尿病 血糖 大鼠 实验研究 

分 类 号：R285.5[医药卫生—中药学]