尼莫地平固体分散体的制备  

Preparation of Nimodipine Solid Dispersion

作　　者：管清香[1] 林天慕[2] 刘晶瑶[3] 狄艳琴[4] 张恒弼[4] 

机构地区：[1]吉林大学药学院药剂教研室,吉林长春130021 [2]第四军医大学吉林军医学院药学教研室 [3]解放军第208医院神经内科 [4]解放军第208医院药剂科

出　　处：《吉林大学学报（医学版）》2003年第1期72-75,共4页Journal of Jilin University：Medicine Edition

摘　　要：目的 :考察水溶性联合载体在增加难溶性药物的溶出速率上是否优于单一载体 ,并制备速释型固体分散体。方法 :分别用 PEG 60 0 0、泊洛沙姆 Poloxamer 1 88及二者不同比例联合做载体制备尼莫地平与载体比为 1∶ 4的固体分散体。 X射线衍射法观察尼莫地平在分散体中的分散状态 ,并通过体外溶出试验考察其溶出速率。结果 :X射线衍射固体分散体中尼莫地平一部分呈分子状态分散 ,另一部分呈微晶状态分散。体外溶出试验中分散体的溶出速率明显快于原料药及物理混合物。结论Objective:To investigate whether the combined carrier is superior to the single carrier in improving dissolution of poorly insoluble water drug and prepare a fast released solid dispersion. Methods: Nimodipine solid dispersion were prepared with PEG6000, Poloxamer 188 as single carriers and combined carriers(which was made of different ratios between the two carriers), respectively. The ratio of nimodipine against carrier(s) in all solid dispersions was 1∶4.X ray power diffraction was used to study the state of nimodipine in the solid dispersions and the dissolution test was used to study the dissolution rate. Results:The results of X ray power diffraction showed that some nimodipine existed as molecular state and others existed as crystallite. Dissolution test in vitro indicated that the dissolution rates of solid dispersions were obviously faster than those of the pure drug and physical mixture. All solid dispersions with PEG6000 and Poloxamer 188 as combined carriers were obviously faster than NM PEG6000 solid dispersion ( P <0.01), but not all faster than NM Poloxamer 188 solid dispersion NM solid dispersion with Poloxamer 188 and PEG6000(1∶15) as combined carrier indicated a faster dissolution rate with t 50 equal to 4.45 min and less Poloxamer 188. Conclusion: The combined carrier is approximately superior to the single carrier in increasing dissolution of poorly insoluble water drug.

关 键 词：尼莫地平 固体分散体 X线衍射 体外溶出速率 

分 类 号：R944.2[医药卫生—药剂学]