均匀设计在丹心痛最佳配比筛选中的应用  

Application of uniform-design method used to select best proportion of ingredients in Danxintong

作　　者：高鹏[1] 安宁飞[2] 赵明宏[3] 刘玉兰[2] 

机构地区：[1]沈阳药科大学药剂教研室,辽宁沈阳110016 [2]沈阳药科大学药理教研室,辽宁沈阳110016 [3]北方医院药剂科,辽宁沈阳110016

出　　处：《中草药》2003年第2期123-125,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的　确定丹心痛 (DXT) 4种成分在处方中的最佳配比。方法　应用均匀设计处理手段与药效学相结合的方法 (大鼠急性心肌缺血模型 )对 DXT中各味药所占比例进行筛选。结果　 DXT中川芎、香附、冰片、丹皮酚的最佳配比为 5∶ 1.7∶ 1.4∶ 4 .4 ,138mg/kg能明显抑制垂体后叶素 (Pit)及异丙肾上腺素 (Iso)致大鼠急性心肌缺血 ,初步药效学实验研究证明 ,DXT有抗心肌缺血的作用。结论　应用均匀设计确定复方药最佳配比的方法是可行的。Object To define the optimal proportion of four ingredients in Danxintong (DXT). Methods Uniform design method combined with pharmacodynamics (Rat acute myocardial ischemia model was used in this study) was used. Results The optimal proportion and components of DXT (Composed of Rhizoma Chuanxiong, Rhizoma Cyperi, Borneolum Syntheticum, and paeonol) were 5∶ 1.7∶ 1.4∶ 4.4; DXT 138 mg/kg could obviously inhibit acute myocardial ischemia of rats induced by iso prenaline (Iso) and pituiturin (Pit). DXT has antimyocardial ischemia effects in preliminary experimental studies. Conclusion Uniform design method is an effective method to define the optimal proportion of ingredients in DXT;

关 键 词：丹心痛 均匀设计 心肌缺血 

分 类 号：R289.1[医药卫生—方剂学]