缓激肽在依那普利对心肌梗死大鼠心肌肥厚及心功能影响中的作用  

Role of bradykinin in the therapeutic effect of enalapril on left ventricular hypertrophy and cardiac function after myocardial infarction in rats

作　　者：张海柱[1] 雷立权[2] 崔长琮[1] 

机构地区：[1]西安交通大学第一医院心内科,陕西西安710061 [2]西安交通大学医学院病理生理学教研室,陕西西安710061

出　　处：《中国病理生理杂志》2003年第2期256-259,共4页Chinese Journal of Pathophysiology

摘　　要：目的 :探讨依那普利 (enalapril)对大鼠心肌梗塞 (M1 )后心肌肥厚及心功能的影响是否与其抑制缓激肽 (BK)降解的途径有关。方法 :将大鼠随机分为 :①假手术对照组 (sham -operatedcontrol) ,②心肌梗死组 (MI) ,③依那普利干预组 (MI+enalapril) ,④依那普利和BKB2 受体阻断剂Hoe - 1 4 0共同干预组 (MI+enalapril+Hoe- 1 4 0 ) ,⑤血管紧张素ⅡⅠ型受体阻断剂losartan干预组 (Ml+losartan)。 3个药物干预组从MI术后第 3d开始给药 ,持续 4周 ,然后测定左心室舒张末压 (LVEDP)、+dp/dtmax及左心室重 /体重 (LVW /BW)、左心室非梗死区组织的平均 (每核 )心肌细胞体积 [V(m)n] ,并进行组间比较。结果 :3个药物干预组的LVEDP、LVW /BW及V(m)n均低于MI组 (均P <O 0 5) ,而 +dp/dtmax和MI组相比无显著差别。 3个药物干预组之间平均动脉压 (MAP)无明显差异 ,但Ml+enalapril+Hoe - 1 4 0组的LVW/BW及V(m)n的值却高于MI+enalapril组。结论 :Enalapril可阻抑大鼠MI后的心肌肥厚并改善左心室功能 ,这种作用的部分机制是由于其促使了心肌组织BK的积累 ,即BK参与了enalapril阻抑心肌肥厚及改善心功能的作用 ,且这些作用不依赖于血压的影响。To investigate the influences of bradykinin(BK)on left ventricular hypertrophy and cardiac function in angiotensin-converting enzyme inhibitor(ACEI) therapy in rats after myocardial infarction. METHODS: The effects of enalapril (500 μg·kg -1 ·d -1 ), enalapril (500 μg·kg -1 ·d -1 )with BKB 2 receptor antagonist (Hoe-140 500 μg·kg -1 ·d -1 ), losartan(3 mg·kg -1 ·d -1 ) on left ventricular end-diastolic pressure (LVEDP), maximum positive left ventricular pressure change (+d p /d t max ) and LVW/BW as well as V(m)n of noinfarcted area were examined after 4 weeks treatment in rats after myocardial infarction. RESULTS: The values of LVEDP, LVW/BW and V(m)n of three treatment groups were higher than that of untreated MI group ( P <0.05),but the +d p /d t max of three treatment groups were not significantly different compared with the untreated MI group. In addition, no significant difference in MAP was observed among the three treatment groups, but the LVW/BW and V(m)n of enalapril+Hoe-140-treated group were higher than that of enalapril-treated group ( P <0.05) .CONCLUSION: Enalapril can prevent left ventricular hypertrophy and improve cardiac function independent of blood pressure after myocardial infarction, which is partly due to the inhibition of BK degradation.

关 键 词：缓激肽 心肌肥厚 心肌梗塞 血管紧张素转换酶抑制剂 大鼠 

分 类 号：R542.2[医药卫生—心血管疾病]