苯那普利对心力衰竭患者血浆血管紧张素Ⅱ、血栓素B_2和6酮-前列腺素浓度的影响  

Effects of lotensin on the plasma level of Ang Ⅱ, TXB_2, 6-keto-PGF_(1a)in patients with chronic congestive heart failure

作　　者：李远重[1] 程芳洲[1] 徐旭燕[1] 成晓岚 

机构地区：[1]咸宁医学院附属医院(咸宁市中心医院)心内科,湖北咸宁437100

出　　处：《中国心血管杂志》2003年第1期25-26,共2页Chinese Journal of Cardiovascular Medicine

摘　　要：目的　探讨苯那普利治疗慢性充血性心力衰竭 (CHF)对肾素 -血管紧张素系统和前列腺素系统的影响。方法　用放射免疫法测定 40例 CHF患者苯那普利治疗 2周前后血浆血管紧张素 (Ang )、血栓素 B2 (TXB2 )、6酮 -前列腺素 (6- keto- PGF1 a)。结果　 CHF患者经苯那普利治疗 2周后血浆 Ang 、TXB2 浓度明显下降 ,6- keto-PGF1 a水平显著升高 ,TXB2 / 6- keto- PGF1 a比值明显下降 (P<0 .0 1) ;血浆 TXB2 的降低与 6- keto- PGF1 a升高呈负相关 (r=- 0 .5 9,P<0 .0 1) ;平均动脉压的下降与 6- keto- PGF1 a的升高呈负相关 (r=- 0 .41,P<0 .0 5 )。结论　苯那普利治疗Objective To study the effects of lotensin on plasma levels of Ang Ⅱ,TXB 2,6 keto PGF 1a in patients with chronic congestive heart failure (CHF).Methods Forty patients with CHF treated with lotensin were observed. The plasma levels of AngⅡ,TXB 2,6 keto PGF 1a were measured by radioimmunoassay before and after treatment of lotensin for two weeks.Results After treatment with lotensin for two weeks, the plasma levels of AngⅡ,TXB 2 were significantly decreased ,that of 6 keto PGF 1a were significantly increased,so the ratio of TXB 2 to 6 keto PGF 1a was significantly decreased ( P <0.01,respectively). The decrease of TXB 2 was inversely related to the increase of 6 keto PGF 1a ( r =-0.59, P <0.01);and decrease of mean artery pressure was inversely related to the increase of 6 keto PGF 1a ( r =-0.41, P <0.05).Conclusion After treatment with lotensin for two weeks, circulatory homeostasis in patients with CHF could be recovered.

关 键 词：充血性心力衰竭 血管紧张素 前列腺素 血栓素B2 苯那普利 

分 类 号：R541.6[医药卫生—心血管疾病]