NGD及NRF对大鼠坐骨神经缺损修复的电生理学检测  

Electrophysiological determination of regeneration of nervous gap by NGD and NRF in rats

作　　者：马红萍[1] 葛锦涛[2] 沈卫星[1] 彭聿平[1] 王晓冬[3] 

机构地区：[1]南通医学院生理学教研室,南通226001 [2]南通医学院生物化学教研室,南通226001 [3]南通医学院分子神经生物学实验室,南通226001

出　　处：《南通医学院学报》2003年第1期1-2,共2页ACTA Academiae Medicinae Nantong

基　　金：国家自然科学基金资助项目 (3 0 0 70 2 5 5);江苏省自然科学基金资助项目 (BK992 0 1)

摘　　要：目的 :观察神经生长液 ( NGD)及神经再生素 ( NRF)修复大鼠坐骨神经缺损的效果。方法 :用生理盐水( NS)、NRF桥接以及 NRF桥接 +口服 NGD修复大鼠坐骨神经缺损 ,术后 12周检测大鼠坐骨神经干动作电位传导速度及肌电图。结果 :行为方面 NGD+ NRF组比 NS组恢复早 ,NS组、NRF组、NRF+ NGD组神经干动作电位传导速度的平均值分别为 5 .72 0 m/ s、16 .5 14 m/ s、2 1.310 m/ s。NS组与 NGD+ NRF组的神经干动作电位传导速度经统计学分析有显著性差异 ( P<0 .0 1)。NGD+ NRF组与 NS组的肌电图比较 ,前者的潜伏期短、峰谷值大、运动神经传导速度快。结论 :NGD+Objective:To assess the regeneration of the sciatic nervous gap by nerve growth decoction (NGD) and nerve regeneration factor (NRF) in rats by the eletrophysiological determination.Methods:The action potential and electromyogram for sciatic nerve in vivo were recorded in the present study to analyze nervous conduct velocity.Results:The wave shape and conduct velocity of action potential as well as electromyogram for the regenerative sciatic nerve by NGD and NRF were markedly different from those of the regenerative nerve by normal saline (NS). Conclusion:The NGD and NRF has a good bridge effect on nervous regeneration.

关 键 词：神经生长液 神经再生素 神经干复合动作电位 大鼠 

分 类 号：R338.8[医药卫生—人体生理学]