中重度妊高征患者血浆NO ET MDA水平及SOD活性变化及其临床意义  

Clinical significance and the changes of plasma NO,ET and MDA level and SOD activity in patients with moderate and severe pregnancy induced hypertension.

作　　者：金红[1] 韩洪健[1] 金延泽[1] 朴贞姬[1] 花玉波[1] 

机构地区：[1]延边大学医学院附属医院妇产科,延吉133000

出　　处：《中国实用妇科与产科杂志》2003年第2期106-107,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨NO、ET和脂质过氧化在妊高征中的作用。方法　对 2 3例中、重度妊高征患者血浆中NO的稳定代谢产物亚硝酸盐 /硝酸盐 (NO-2 /NO-3)、ET 1、MDA水平及SOD活性进行测定。结果　中、重度妊高征组与正常晚期妊娠组比较 ,各指标均有显著性差异 (P <0 0 1) ;妊高征患者NO/ET值与SOD/MDA值呈显著正相关 (r =0 895 0 ,P <0 0 1) ;而MAP与NO/ET值呈显著负相关 (r =- 0 844 7,P <0 0 1)。Objective To study the role of NO,ET and lipid peroxidation in pregnancy induced hypertension.Methods The plasma NO - 2/NO - 3,ET 1,MDA concentrations and SOD activity were examined in 23 PIH patients,20 normal pregnant women and 20 normal non pregnant women.Results There were significant changes of all indexes between moderate,severe PIH groups and normal pregnant group (P<0 01);There was apparently positive correlation between the NO/ET and SOD/MDA value (r=0 8950,P<0 01),while apparently negative correlation between MAP and NO/ET value (r=-0 8447,P<0 01).Conclusion The occurrence of PIH is related to the imbalance of NO/ET induced by the lipid peroxidation.

关 键 词：血浆 NO ET MDA SOD活性 临床意义 妊娠高血压综合征 

分 类 号：R714.246[医药卫生—妇产科学]