65岁以上老年人地氟醚肺泡气最低有效浓度测定  

Minimum alveolar concentration of desflurane in the elderly

作　　者：孙立[1] 张宏[1] 宋运琴[1] 

机构地区：[1]中国人民解放军总医院麻醉科,北京市100853

出　　处：《临床麻醉学杂志》2003年第2期72-73,共2页Journal of Clinical Anesthesiology

摘　　要：目的　测定我国 6 5岁以上老年人地氟醚的肺泡气最低有效浓度 (MAC)。方法　选择ASAⅠ～Ⅱ级择期手术的 6 5岁以上患者 ,术前检查排除肝、肾、脑及心脏系统疾病 ,无酗酒史 ,无术前用药。入室后常规监测心电图、无创血压及血氧饱和度。氧和 3%地氟醚吸入诱导插管 ,全凭吸入地氟醚麻醉。采用Dixon’sup and down方法 ,交叉出现 6对切皮不动 动的患者即终止。 6对切皮不动 动患者切皮时地氟醚浓度的平均值即为MAC。结果　 17例患者中出现 6对不动 动的交叉对 ,MAC为 (5 0 8± 0 2 6 ) %。结论　老年人地氟醚MAC较文献报道的年轻人MAC小。Objective To determine the minimum alveolar concentration (MAC) of desflurane in Chinese patients older than 65 yrs.Methods Anesthesia was induced by inhalation of oxygen and 3% desflurane in seventeen patients without the liver,kidney or brain diseases and having no premedication.The concentration of desflurane was determined using a modification of Dixons up and down method.Six crossover pairs of patient responses provided a mean end tidal concentration.MAC was the average of the six crossover midpoints.Results MAC was (5 08±0 26)% in Chinese patients older than 65 yrs.Conclusion In Chinese patients older than 65 yrs,MAC of desflurane is less than that reported in the foreign youngers.Geriatrics;Desflurane;Minimum alveolar concentration

关 键 词：65岁以上老年人 地氟醚 肺泡气最低有效浓度 麻醉药 浓度测定 

分 类 号：R614[医药卫生—麻醉学]