新型气体分子硫化氢参与高血压形成机制  

Endogenous H_2S is involved in the development of spontaneous hypertension

作　　者：杜军保[1] 闫辉[1] 唐朝枢[2] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学心血管研究所,北京100034

出　　处：《北京大学学报（医学版）》2003年第1期102-102,共1页Journal of Peking University:Health Sciences

基　　金：国家重点基础研究发展规划 (973 )项目 (G2 0 0 0 0 5 690 5 );北京大学心血管重大研究项目 (985 )资助~~

摘　　要：Hydrogen sulfide (H 2S) is recently found to be a new gaseous messenger playing an important role in many physiological and pathophysiological processes. The aim of this study was to explore the changes in endogenous H 2S pathway and examine the effects of H 2S on the development of spontaneous hypertensive rats (SHR). A controlled study on SHR and WKY rats at the age of 4 weeks showed that after 5 weeks of experiment, the blood pressure of SHR was markedly increased as compared with WKY rats (183.57±11.80 mm Hg vs 107.5± 22.68 mm Hg, P <0.05)and the ratio of left heart weight to whole heart weight of SHR was also increased as compared with WKY rats (0.85±0.02 vs 0.83±0.02, P <0.05). While, the aortic H 2S producing rate and H 2S plasma level were decreased in SHR compared with WKY rats (15.63±2.89 nmol·min -1 ·g -1 vs 25.31± 5.99 nmol·min -1 ·g -1 , 20.35±9.20 μmol·L -1 vs 48.40±13.36 μmol·L -1 , P <0.05). NaHS, however, attenuated the high blood pressure and the ratio of left heart weight to whole heart weight of SHR (158.13± 12.52 mm Hg vs 183.57±11.80 mm Hg and 0.83±0.03 vs 0.85±0.02), respectively. The above findings suggested that the reduced production of endogenous H 2S was important in the development of spontaneous hypertension. The authors also observed that 5 weeks after the experiment the relaxing rate of aortic rings in response to acetylcholine in SHR was higher than that of WKY rats and NaHS enhanced the relaxingresponse of aortic rings to acetylcholine in SHR significantly( P <0.05). The aortic relaxing activities in both SHR and WKY rats displayed a dose dependent response to different doses of NaHS. In conclusion, the reduced production of endogenous H 2S in aorta is involved in the pathogenesis of spontaneous hypertension and is of great biological importance in modulating vasorelaxation.Hydrogen sulfide (H 2S) is recently found to be a new gaseous messenger playing an important role in many physiological and pathophysiological processes. The aim of this study was to explore the changes in endogenous H 2S pathway and examine the effects of H 2S on the development of spontaneous hypertensive rats (SHR). A controlled study on SHR and WKY rats at the age of 4 weeks showed that after 5 weeks of experiment, the blood pressure of SHR was markedly increased as compared with WKY rats (183.57±11.80 mm Hg vs 107.5± 22.68 mm Hg, P <0.05)and the ratio of left heart weight to whole heart weight of SHR was also increased as compared with WKY rats (0.85±0.02 vs 0.83±0.02, P <0.05). While, the aortic H 2S producing rate and H 2S plasma level were decreased in SHR compared with WKY rats (15.63±2.89 nmol·min -1 ·g -1 vs 25.31± 5.99 nmol·min -1 ·g -1 , 20.35±9.20 μmol·L -1 vs 48.40±13.36 μmol·L -1 , P <0.05). NaHS, however, attenuated the high blood pressure and the ratio of left heart weight to whole heart weight of SHR (158.13± 12.52 mm Hg vs 183.57±11.80 mm Hg and 0.83±0.03 vs 0.85±0.02), respectively. The above findings suggested that the reduced production of endogenous H 2S was important in the development of spontaneous hypertension. The authors also observed that 5 weeks after the experiment the relaxing rate of aortic rings in response to acetylcholine in SHR was higher than that of WKY rats and NaHS enhanced the relaxingresponse of aortic rings to acetylcholine in SHR significantly( P <0.05). The aortic relaxing activities in both SHR and WKY rats displayed a dose dependent response to different doses of NaHS. In conclusion, the reduced production of endogenous H 2S in aorta is involved in the pathogenesis of spontaneous hypertension and is of great biological importance in modulating vasorelaxation.

关 键 词：硫化氢 药理学 高血压 药物作用 病理生理学 

分 类 号：R544.105[医药卫生—心血管疾病]