修饰蚯蚓纤溶酶的药代动力学研究  

Studies on Pharmacokinetics of Modified Fibrinolytic Enzyme from Pheretima

作　　者：伍晓斌[1] 王雪英[2] 徐凤彩[3] 

机构地区：[1]中国科学院微生物研究所,北京100080 [2]湖北农学院生命科学院,荆州434025 [3]华南农业大学生命科学院,广州510642

出　　处：《药物生物技术》2003年第1期37-39,共3页Pharmaceutical Biotechnology

基　　金：广东省高教厅基金(200001)

摘　　要：环毛蚓纤溶酶经聚乙二醇(PEG)和β-环糊精(β-CD)修饰后,分别静脉注射到猪体内和兔体内进行药代动力学研究。结果表明PEG-EFE在猪体内的半衰期为0.96 h,而原酶在猪体内的半衰期为0.59h,PEG-EFE较原酶提高了1.62倍。β-CD-EFE注射于兔体内的药代动力学证明,β-CD-EFE在兔体内的分布相半衰期为1.00h,而原酶仅为0.65 h,β-CD-EFE较原酶的体内半衰期提高了1.52倍。说明2种修饰方法都是有效的。Fibrinolytic enzyme from Pheretima was modified with activated PEG4000 and β-cyclodextin(β-CD). The pharmacokinetics of modified fibrinolytic enzymes were studied and the result suggested the half-life of the PEG-EFE was 0.97h while that of the free EFE was 0.59h in vivo of pigs. The half-life of the β-CD -EFE was 1 .00h while that of the free EFE was 0.65h in vivo of rabbits.

关 键 词：修饰纤溶酶 PEG-EFE β-CD-EFE 药代动力学 

分 类 号：R977.3[医药卫生—药品] Q556.9[医药卫生—药学]